نتایج جستجو برای: lung delivery

تعداد نتایج: 508290  

2010
Manjeet Deshmukh Piyun Chao Hilliard L. Kutscher Dayuan Gao Patrick J. Sinko

The objective of the present study was to identify a camptothecin (CPT) prodrug with optimal release and cytotoxicity properties for immobilization on a passively targeted microparticle delivery system. A series of R-amino acid ester prodrugs of CPT were synthesized, characterized, and evaluated. Four CPT prodrugs were synthesized with increasing aliphatic chain length (glycine (Gly) (2a), alan...

Journal: :The Journal of antimicrobial chemotherapy 1996
S Hashimoto E Wolfe B Guglielmo R Shanks J Sundelof J F Pittet E Thomas J Wiener-Kronish

Aerosolization of imipenem/cilastatin was compared with continuous intravenous infusions of the antibiotic for pharmacokinetic/pharmacodynamic analysis. The concentrations of imipenim/cilastatin in bronchoalveolar lavage fluids (BAL) obtained from rats exposed to the aerosolized antibiotic were significantly greater than the concentrations in BAL in the rats that had received intravenous infusi...

2016
Jagadevappa Patil

Drug delivery strategies become scientific temperament during present day research arena. Pharmacotherapeutics can be successfully delivered through pulmonary route and this approach has captivated excellent scientific and biomedical attention in recent years. This approach has shown substantial progress within the context of local treatment for respiratory disorders, due to the augmented local...

2015
Javed Ahmad Sohail Akhter Md Rizwanullah Saima Amin Mahfoozur Rahman Mohammad Zaki Ahmad Moshahid Alam Rizvi Mohammad A Kamal Farhan Jalees Ahmad

Considering the challenges associated with conventional chemotherapy, targeted and local delivery of chemotherapeutics via nanoparticle (NP) carriers to the lungs is an emerging area of interest. Recent studies and growing clinical application in cancer nanotechnology showed the huge potential of NPs as drug carriers in cancer therapy, including in lung carcinoma for diagnosis, imaging, and the...

Journal: :The European respiratory journal 2014
Sabine H van Rijt Thomas Bein Silke Meiners

Respiratory diseases are an increasing burden for the ageing population. Although our understanding of these diseases has improved significantly over the past decades, diagnostic and therapeutic options for treating lung diseases, such as chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis and lung cancer, remain limited. Multidisciplinary approaches that bridge the gap between...

Journal: :Acta bio-medica : Atenei Parmensis 2014
G Gargano S Braibanti

The aim of neonatal resuscitation is to establish an effective ventilation, avoiding lung damage. PEEP and T-piece use, as well as Sustained Lung Inflation, lower O2 target and appropriately timed surfactant administration analyzed. A new "gentle" respiratory approach in delivery room can improve newborn respiratory outcome.

Journal: :iranian journal of immunology 0
mohamed shehata ali mohamed department of thoracic transplantation, university clinic essen, essen, germany

the introduction of ex vivo lung perfusion (evlp) in the practice of lung transplantation has allowed the reconditioning of the marginal grafts and their conversion into transplantable grafts. in addition, evlp can provide a platform for the application of various preventive measures to decrease the incidence of post-transplant complications. while the toronto team targets the attenuation of th...

Journal: :Equine veterinary journal 2011
F R Bertin K M Ivester L L Couëtil

REASONS FOR PERFORMING STUDY Studies investigating the clinical efficacy of albuterol administered with the same propellant and commercially available delivery devices in horses with recurrent airway obstruction (RAO) are not currently available. OBJECTIVES To determine the efficacy of aerosolised albuterol administered to horses with RAO by means of 2 commercially available, hand-held delive...

Journal: :Respiratory care 2005
Joseph L Rau

Inhalation is a very old method of drug delivery, and in the 20th century it became a mainstay of respiratory care, known as aerosol therapy. Use of inhaled epinephrine for relief of asthma was reported as early as 1929, in England. An early version of a dry powder inhaler (DPI) was the Aerohalor, used to administer penicillin dust to treat respiratory infections. In the 1950s, the Wright nebul...

Journal: :Journal of immunology 2011
Suhas G Kallapur Boris W Kramer Christine L Knox Clare A Berry Jennifer J P Collins Matthew W Kemp Ilias Nitsos Graeme R Polglase James Robinson Noah H Hillman John P Newnham Claire Chougnet Alan H Jobe

The chorioamnionitis associated with preterm delivery is often polymicrobial with ureaplasma being the most common isolate. To evaluate interactions between the different proinflammatory mediators, we hypothesized that ureaplasma exposure would increase fetal responsiveness to LPS. Fetal sheep were given intra-amniotic (IA) injections of media (control) or Ureaplasma parvum serovar 3 either 7 o...

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