objective(s): foxp3 gene is an x-linked gene that encodes foxp3 protein, an essential transcription factor in cd4+cd25+foxp3+ regulatory t (treg) cells.  we aimed, in the present study, to investigate the association of two foxp3 polymorphisms, -2383 c/t (rs3761549) and ivs9+459 t/c (rs2280883), with lung cancer. materials and methods:  in a case-control study we analyzed genotypes and alleles ...

background: mehr-80 is a newly established adherent human large cell lung cancer cell line that has not been transfected until now. this study aims to define the optimal transfection conditions and effects of some critical elements for enhancing gene delivery to this cell line by utilizing different non-viral transfection procedures. methods: in the current study, calcium phosphate (cap), deae-...

abstractobjective: to investigate the impact of respiratory motion on localization, and quantification lung lesions for the gross tumour volume utilizing an in-house developed auto3dreg programme and dynamic nurbs-based cardiac-torso digitised phantom (ncat). methods: respiratory motion may result in more than 30% underestimation of the suv values of lung, liver and kidney tumour lesions. the m...

Centrally located lung cancers in smokers frequently associated with subsequent primary tumors. We evaluated the telomerase expression chronologically in noncancerous epithelia as a risk factor of susceptibility to lung cancer development. Telomerase protein expression was examined in situ by immunohistochemistry in 26 noncancerous bronchial epithelia adjacent to centrally located early-stage l...

introduction: although extensive research has been conducted on lung cancer markers, a singular clinically applicable marker has not been found yet. the objective of this study was to evaluate the sensitivity and the specificity of carcinoembryonic antigen (cea) mrna and lung-specific x protein (lunx) mrna biomarkers in peripheral blood to detect lung cancer individually and simultaneously. met...

abstract background: lung cancer is an important cause of cancer mortality. mortality is a familiar projection to address the burden of cancers. however, according to iranian death registry, about 20% of death statistics were still recorded in misclassified categories. the aim of this study was to estimate lung cancer mortality in iranian population, using bayesian approach to revise this miscl...

PURPOSE To quantify the effect of reduced life expectancy on cancer risk by comparing estimated lifetime risks of lung cancer attributable to radiation from commonly used computed tomographic (CT) examinations in patients with and those without cancer or cardiac disease. MATERIALS AND METHODS With the use of clinically determined life tables, reductions in radiation-attributable lung cancer r...

Metformin, a commonly used anti-diabetic drug has emerged as a potential anti-cancer drug. Over the last few years, a mass of epidemiologic, outcomes and preclinical data has emerged demonstratic the potential clinical relevance and the mechanistic basis of the anti-cancer activity of this well tolerated drug in lung cancer. This review article summarizes this evidence that supports the trial o...