Calcium channel blockers (CCBs) are widely used to treat cardiovascular disease (CVD) including hypertension. As aging is an independent risk factor for CVD, the use of CCBs increases with increasing age. Hence, this study was designed to evaluate the effect of aging on the sensitivity of small mesenteric arteries to L-type voltage-gated calcium channel (LTCC) blockers and also to investigate w...

The apoptosis of cerebellar granule neurons (CGN) induced by low-potassium in serum free medium in vitro has become a widely used model for neuronal apoptosis during in vivo brain development. In this review we shall summarize first the basic features of this model for neuronal apoptosis. Next, we shall focus on the L-type calcium channels (LTCC) inactivation as the primary pro-apoptotic signal...

Kudryavtseva O, Herum KM, Dam VS, Straarup MS, Kamaev D, Boedtkjer DM, Matchkov VV, Aalkjær C. Downregulation of L-type Ca channel in rat mesenteric arteries leads to loss of smooth muscle contractile phenotype and inward hypertrophic remodeling. Am J Physiol Heart Circ Physiol 306: H1287–H1301, 2014. First published February 21, 2014; doi:10.1152/ajpheart.00503.2013.—Ltype Ca channels (LTCCs) ...

The four lectures follow closely a textbook on Potential Theory in the Complex Plane by T. Ransford, apart from material on harmonic measure which has been borrowed from a lecture course Introduction to Potential Theory with Applications, by C. Kuehn. The material in lecture 5 is borrowed from a survey Logarithmic Potential Theory with Applications to Approximation Theory by E. B. Saff (E-print...

With the rapid development of microelectronic information technology, packaging has higher requirements in terms integration density, signal transmission speed, and passive component integration. Low temperature co-fired ceramics (LTCC) exhibit excellent dielectric properties low sintering properties, which meets above-mentioned requirements. This work investigates effects CaF2 doping (0–16 mol...

LTCC-M (Low Temperature Co-fired Ceramic on Metal) technology is described in terms of structural characteristics, materials and processes. Much works on material systems to minimize thermal mismatches and barrier formation processes to have uniform height and shape are introduced and some results from the fabrication of back panels having barrier ribs in 165 μm pitch are shown. Finally, furthe...