This article is intended to provide an overview of various aspects of clinical PET/CT. These include discussions of: (i) Important areas of clinical application; (ii) Opportunities in clinical research; (iii) Scanner and operating-mode considerations (e.g. BGO vs. LSO, LYSO or GSO scanners, 2D vs. 3D imaging). (iv) Study-specific considerations (e.g. patient preparation and positioning is...

Title: NEUROMORPHIC VLSI REALIZATION OF THE HIPPOCAMPAL FORMATION AND THE LATERAL SUPERIOR OLIVE Anu Aggarwal, Doctor of Philosophy, 2015 Directed by: Prof Robert W. Newcomb Department of Electrical and Computer Engineering In this work, the focus is on realizing the function of the hippocampal formation (HF) and the lateral superior olive (LSO) in electronic circuits. The first major contribut...

The initial processing of interaural intensity differences (IIDs), the major cue to the azimuthal location of high-frequency sounds in mammals, is carried out by neurons in the lateral superior olivary nucleus (LSO) that receive excitatory input from the ipsilateral ear and inhibitory input from the contralateral ear (IE neurons). The "latency" hypothesis asserts that it is the effects of inten...

Let X be a (not necessarily reduced) complex analytic space, and let F be a germ of an analytic space. The locus of points q in X at which the germ Xq is complex analytically isomorphic to F is studied. If it is nonempty it is shown to be a locally closed submanifold of X, and X is locally a Cartesian product along this submanifold. This is used to define what amounts to a coarse partial orderi...

How does the brain accomplish sound localization with invariance to total sound level? Sensitivity to interaural level differences (ILDs) is first computed at the lateral superior olive (LSO) and is observed at multiple levels of the auditory pathway, including the central nucleus of inferior colliculus (ICC) and auditory cortex. In LSO, this ILD sensitivity is level-dependent, such that ILD re...

We studied the performance of a dual-panel positron emission tomography (PET) camera dedicated to breast cancer imaging using Monte Carlo simulation. The PET camera under development has two 10x 15 cm(2) plates that are constructed from arrays of I X 1 X 3 mm(3) LSO crystals coupled to novel ultra-thin (<200 Am) silicon position-sensitive avalanche photodiodes (PSAPD). In this design the photod...

UNLABELLED Lutetium oxyorthosilicate (LSO)- or lutetium-yttrium oxyorthosilicate (LYSO)-based PET scanners have intrinsic radioactivity in the scintillator crystals due to the presence of (176)Lu, which decays by beta-emission followed by one or more prompt gamma-ray emissions. This leads to intrinsic true counts that can influence the image when scanning low levels of activity. An evaluation o...

The LSO Workshop series has focused on technical, organizational, and social solutions to problems of learning from past experiences and codifying the resulting best practices so they can be systematically used in subsequent software development efforts. The theme of the Fourth Workshop on Learning Software Organizations (LSO), held in Chicago, Illinois in August of 2002 was "Balancing Agile Pr...

Emerging applications for positron emission tomography (PET) may require the ability to image very low activity source distributions in the body. The performance of clinical PET scanners in the regime where activity in the field of view is <1 MBq has not previously been explored. In this study, we compared the counting rate performance of two clinical PET/CT scanners, the Siemens Biograph Revea...

GABAergic and glycinergic circuits are found throughout the auditory brainstem, and it is generally assumed that transmitter phenotype is established early in development. The present study documents a profound transition from GABAergic to glycinergic transmission in the gerbil lateral superior olive (LSO) during the first 2 postnatal weeks. Whole-cell voltage-clamp recordings were obtained fro...