The electronic structure of f-electron systems is calculated with the selfinteraction-corrected local-spin-density (LSD) approximation. This scheme allows for a splitting of the f-electron manifold into an integral number of localized electrons and self-consistently determined fractional number of band electrons. Therefore, in comparison with the LSD approximation, where all f states are pinned...

LSD and similar hallucinogenic drugs have at present acquired a cultural connotation as dangerous drugs that can lead to mental disorders and anti-social behaviour.' At one time, however, these drugs showed promise for medical use in psychotherapy and neuropharmacology, and in research into psychosis. Use of LSD was enthusiastically advocated by numerous psychiatrists from diverse cultural back...

BACKGROUND Early diagnosis of lysosomal storage disorders (LSDs), before the onset of irreversible pathology, will be critical for maximum efficacy of many current and proposed therapies. To search for potential markers of LSDs, we measured saposins A, B, C, and D in patients with these disorders. METHODS Four time-delayed fluorescence immunoquantification assays were used to measure each of ...

2 studies, involving 69 male inmates of an experimental penal institution, investigated the psychological states produced by LSD as compared with amphetamine and placebo controls. A number of scales on a newly developed subjective drug-effects questionnaire significantly differentiated the groups. This instrument was further used to identify 3 qualitatively different subjective states produced ...

Merkel cell polyomavirus (MCV) causes an aggressive human skin cancer, Merkel cell carcinoma, through expression of small T (sT) and large T (LT) viral oncoproteins. MCV sT is also required for efficient MCV DNA replication by the multifunctional MCV LT helicase protein. We find that LT is targeted for proteasomal degradation by the cellular SCF(Fbw7) E3 ligase, which can be inhibited by sT thr...

A total of 2259 urine samples were assayed for lysergic acid diethylamide (LSD) using radioimmunoassay (RIA, Coat-a-Count, Diagnostics Products) and a premarket cloned enzyme donor immunoassay (CEDIA, Boehringer Mannheim). Urine samples were obtained from patients admitted to the emergency room, patients in drug rehabilitation programs, and adults and juveniles in criminal probation programs. A...

The present study investigated interactions between the novel psychoactive tryptamines DiPT, 4-OH-DiPT, 4-OH-MET, 5-MeO-AMT, and 5-MeO-MiPT at monoamine receptors and transporters compared with the classic hallucinogens lysergic acid diethylamide (LSD), psilocin, N,N-dimethyltryptamine (DMT), and mescaline. We investigated binding affinities at human monoamine receptors and determined functiona...

In this paper, we cover the process of integrating Large-Scale Direct Simultaneous Localization and Mapping (LSD-SLAM) [1] algorithm into our existing AR stereo engine, developed for our modified ”Augmented Reality Oculus Rift”. With that, we are able to track one of our realworld cameras which are mounted on the rift, within a complete unknown environment. This makes it possible to achieve a c...

This paper reports on the effects of LSD on mental time travel during spontaneous mentation. Twenty healthy volunteers participated in a placebo-controlled crossover study, incorporating intravenous administration of LSD (75 μg) and placebo (saline) prior to functional magnetic resonance imaging (fMRI). Six independent, blind judges analysed mentation reports acquired during structured intervie...

The 3-pentyl-, (R)- and (S)-2-pentyl-, 2-hexyl-, and 2-heptylamides of d-lysergic acid were synthesized and evaluated in biochemical and behavioral assays for LSD-like activity. In radioligand competition studies, the (R)-lysergamides were consistently more potent than the (S)-amides in displacing [3H]ketanserin from 5-HT2A receptors in rat cortical homogenate and in displacing [3H]-8-OH-DPAT (...