A new method that allows rapid phenotyping of genetic Lp(a) glycoprotein types in large numbers of samples is described. The method is based on sodium dodecyl sulfate gel electrophoresis of reduced serum or plasma in horizontal slab gels followed by immunoblotting with polyclonal anti-Lp(a) lipoprotein or monoclonal anti-Lp(a) glycoprotein antibodies. Phenotyping of 194 unrelated, healthy subje...

Sera from 11 individuals which were classified as Lp(a-) by direct gel diffusion and by absorption tests showed the presence of Lp(a) lipoprotein when the sera were concentrated 120-fold. This Lp(a) antigen was demonstrated by gel diffusion to be indistinguishable from Lp-lipoprotein isolated from known Lp(a+) sera. The Lp(a) preparations from sera classified Lp(a-) also showed electrophoretic ...

The Johnson-Lindenstrauss Lemma shows that any set of n points in Euclidean space can be mapped linearly down to O((log n)/ǫ) dimensions such that all pairwise distances are distorted by at most 1 + ǫ. We study the following basic question: Does there exist an analogue of the JohnsonLindenstrauss Lemma for the l1 norm? Note that Johnson-Lindenstrauss Lemma gives a linear embedding which is inde...

We show that any embedding of the level k diamond graph of Newman and Rabinovich [6] into Lp, 1 < p ≤ 2, requires distortion at least √ k(p− 1) + 1. An immediate corollary is that there exist arbitrarily large n-point sets X ⊆ L1 such that any D-embedding of X into l1 requires d ≥ n Ω(1/D2). This gives a simple proof of a recent result of Brinkman and Charikar [2] which settles the long standin...

In this paper we study the problem of computing the smallest-width annulus for a convex polytope in R d. This generalizes a topic from tolerancing metrology to higher dimensions, of which the planar case has been investigated by Swanson, Lee and Wu. We show this problem to be equivalent to the problem of computing diierent variants of Hausdorr-minimal spheres. We can formulate the latter proble...

There are errors in the author affiliations. The affiliations should appear as shown here: Ana Wheelock, MSc; Anam Parand, PhD; Bruno Rigole, MSc; Angus Thomson, PhD; Marisa Miraldo, PhD; Charles Vincent, PhD; Nick Sevdalis, PhD Faculty of Medicine, Imperial College London, London, UK; Sanofi Pasteur, Lyon, France; Imperial College Business School, London, UK; Department of Experimental Psychol...

This paper presents a historical overview and current perspective of the Automated Neuropsychological Assessment Metrics (ANAM) test system. We discuss the history of its development along with a synopsis of the evolution of computerized testing that has occurred and led to ANAM over the past 30 years within the Department of Defense (DoD). We include a description of our current system and tes...

The purpose of this paper is to discuss how a recently proposed RT (Register Transfer) Level test preparation methodology can be reused to drive innovative LowEnergy (LE) / Low-Power (LP) BIST solutions for digital SOC (System on a Chip) embedded cores. RTL test generation is carried out through the definition of a reduced set of masks, forcing few "care" bits, and leading to a high correlation...