We have examined the effects of a siRNA targeting the Egr-1, alone or in combination with the breast cancer therapeutic camptothecin (Cpt), in suppressing breast cancer cell survival and anchorage-independent growth in the breast cancer cell lines SK-BR3 and MCF-7. In mammary and lung tumors, as well as most normal tissues, Egr-1 expression is low, suggesting a possible relation between the low...

Expression of early growth response (Egr)-1, a transcriptional factor implicated in growth regulation, is suppressed in several malignant tumors. The present study investigated the expression of Egr-1 and related genes in uterine leiomyoma and normal myometrium to determine possible contributions of Egr-1 to neoplastic growth in leiomyoma cells. Levels of Egr-1 transcripts were decreased in all...

Expression of early growth response (Egr)-1, a transcriptional factor implicated in growth regulation, is suppressed in several malignant tumors. The present study investigated the expression of Egr-1 and related genes in uterine leiomyoma and normal myometrium to determine possible contributions of Egr-1 to neoplastic growth in leiomyoma cells. Levels of Egr-1 transcripts were decreased in all...

This paper reports the results of an experimental investigation on the effect of the EGR on the pollutants emission, especially on oxides of nitrogen, from the exhaust gases and performance of the spark ignition engine. Also along with experimental work, a mathematical model for the determination of the effect of EGR on the peak cycle temperature and for the prediction of its effect on the NOx ...

As the impacts of global warming have become increasingly severe, oxy-fuel combustion has been widely considered a promising solution for carbon capture and storage (CCS) to reduce dioxide (CO2) achieve net-zero emissions. In past few decades, researchers around world demonstrated improvements by application internal (IC) engines. This article presents comprehensive review experimental simulati...

The purpose of this article is to describe the design of a limited stroke actuator and the corresponding prototype to drive a Low Pressure (LP) Exhaust Gas Recirculation (EGR) valve for use in Internal Combustion Engines (ICEs). The direct drive actuator topology is an axial flux machine with two air gaps in order to minimize the rotor inertia and a bipolar surface-mounted permanent magnet in o...

Abstract: Properly understanding heat flux characteristics is a crucial prerequisite to efficiently applying a regenerative burner in an aluminum reheating furnace. A series of experiments was conducted in this study in order to establish a database of the best available burners according to furnace temperature, excess air ratio, and flame combustion mode as they affect heat flux characteristic...

It is attempt in pulverized coal injection (PCI) in blast furnace tuyeres to increase the injection rate without increasing the amount of unburned char inside the stack of the blast furnace. The unburned char can cause problems in the blast furnace operation, such as reduced permeability, undesirable gas/temperature distribution, excessive coke erosion and significant char carryover. In the nea...

prove the dissolution property and oral bioavailability of poorly water-soluble drugs, solid dispersion methods have been extensively used and numerous approaches have been reported such as fusion, solvent evaporation, and spray-drying methods. However, these methods involve various problems. Solid dispersions prepared by fusion usually have the shortcoming of being tacky and unstable, and solv...