Cis-regulatory sequences are not always conserved across species. Divergence within cis-regulatory sequences may result from the evolution of species-specific patterns of gene expression or the flexible nature of the cis-regulatory code. The identification of functional divergence in cis-regulatory sequences is therefore important for both understanding the role of gene regulation in evolution ...

1. Data show suicidal behavior often is precipitated by individuals' experience of loss by suicide. This article focuses on three potential links between the two phenomena (i.e., grief experienced by suicide survivors and familial risk factors for suicide; suicide clusters and pacts; consequences of mass media portrayals of suicide). 2. Suicide bereavement has certain typical characteristics th...

We propose algorithms of adaptive integration for calculation of the tail probability in multi-factor credit portfolio loss models. We first devise the classical Genz-Malik rule, a deterministic multiple integration rule suitable for portfolio credit models with number of factors less than 8. Later on we arrive at the adaptive Monte Carlo integration, which simply replaces the deterministic int...

Patients with diabetes mellitus often show symptoms such as dizziness, tinnitus, and hearing impairment. In general, hearing loss is sensorineural, which is sometimes confused with presbycusis, mainly because it develops in patients older than 40 years of age. Angiopathy and neuropathy caused by diabetes mellitus have been considered important factors for the vestibular-cochlear disorders found...

Background: Alopecia is a possible adverse reaction to Tumor Necrosis Factor alpha (TNF-α) inhibitors. This side effect has become more recognized in recent years through FDA postmarketing surveillance and it description in case reports/case series. Objective: We review the literature and summarize the pathogenesis, clinical presentation, prognosis, and management strategies for TNF-α inhibitor...

AIM To identify likely association between blood hypertension and hearing loss. DESIGN A non-paired case-control study. SETTING Institutional work carried out at Universidade Norte do Paraná, in South Brazil. MATERIAL AND METHOD 154 cases and 154 controls, both genders, aged 45 to 64, included in the research after sample estimation. METHODOLOGY Hypertension was verified through blood p...

BACKGROUND Drug abuse is one of the most important public health problems worldwide as in Iran. The aim of present study was to determine whether opium addiction can affect bone mineral density or not. METHODS Fifty opium addicted and 50 non-addicted volunteer men aged between 25-45 were enrolled. The subjects with positive history of other osteoporosis risk factors were excluded. The vertebr...

The problem of damping representation and measurement is investigated. Among the many parameters found in literature, the most comprehensive is loss factor 'l· Several definitions of '7 are feasible, but in linear problems they all should reduce to the ratio of the in-phase and quadrature parts of the associated complex modulus. This work surveys measuring methods for materials and structures w...