We developed a new statistical framework to find genetic variants associated with extreme longevity. The method, informed GWAS (iGWAS), takes advantage of knowledge from large studies of age-related disease in order to narrow the search for SNPs associated with longevity. To gain support for our approach, we first show there is an overlap between loci involved in disease and loci associated wit...

Rapamycin treatment is considered a pharmacological intervention with the potential to mimic the longevity benefits of dietary manipulations. However, how rapamycin interacts with nutrition is not fully understood. Here we studied the effect of rapamycin on the longevity of Drosophila under a range of dietary conditions. In diets low in nutrients, rapamycin reduced longevity in a dosage-depende...

Digital longevity has emerged as a key challenge for information systems in many domains. In this article we explore the hypothesis that longevity is a non-functional quality attribute of information and software artifacts, driven by organizational capabilities and sociotechnical change processes. While software evolution and maintenance have produced a rich body of knowledge on keeping softwar...

With substantial fixed costs of drug development, more common conditions can support more products. If additional pharmaceutical products are beneficial, they will attract greater consumption and promote better health, e.g. greater longevity. We ask how market size – measured by condition prevalence – affects consumption and longevity. We document in condition cross sections that both the tende...

Several pathologies such as neurodegeneration and cancer are associated with aging, which is affected by many genetic and environmental factors. Healthy aging conceives human longevity, possibly due to carrying the defensive genes. For instance, FOXO (forkhead box O) genes determine human longevity. FOXO transcription factors are involved in the regulation of longevity phenomenon via insulin an...

Nutritional environments, particularly those experienced during early life, are hypothesized to affect longevity. A recent cross-taxa meta-analysis found that, depending upon circumstance, average longevity may be increased or decreased by early-life dietary restriction. Unstudied are the effects of diet during development on among-individual variance in longevity. Here, we address this issue u...

The molecular genetic analysis of longevity of Caenorhabditis elegans has yielded fundamental insights into evolutionarily conserved pathways and processes governing the physiology of aging. Recent studies suggest that interactions between C. elegans and its microbial environment may influence the aging and longevity of this simple host organism. Experimental evidence supports a role for bacter...

A “radiosensitivity index” (LTJmean longevity) was correlated with the mean longevity and dry weight of 37 insect species (both sexes of 12 species) representing eight orders. Curvilinear regression analysis reIating radiosensitivity to mean longevity and mean dry weight indicated that 46.3% of the observed variation could be attributed to longevity and 32.6% to the dry weight of the species. I...

Knowledge of strong predictors of mortality and longevity is very important for actuarial science and practice. Earlier studies found that parental characteristics as well as early-life conditions and midlife environment play a significant role in survival to advanced ages. However, little is known about the simultaneous effects of these three factors on longevity. This ongoing study attempts t...

Longevity is a highly desirable trait that considerably affects overall profitability. With increased longevity the mean production of the herd increases because a greater proportion of the culling decisions are based on production and the proportion of mature cows, which produce more milk than young, cows is increased. An increased longevity enables higher selection intensity of females and th...