PURPOSE Temozolomide (TMZ) is an alkylating agent licensed for treatment of high-grade glioma (HGG). No prospective comparison with nitrosourea-based chemotherapy exists. We report, to our knowledge, the first randomized trial of procarbazine, lomustine, and vincristine (PCV) versus TMZ in chemotherapy-naive patients with recurrent HGG. PATIENTS AND METHODS Four hundred forty-seven patients w...

Background. Alkylating drugs have been used in tumor chemo therapy for many decades, and the search effective compounds continues. The aim of study was to activity developed new compound – 2-[3-(2-chloroethyl)-3-nitrosoureido]-1,3-propanediol (chlonisol) comparison with lomustine (CCNU) from nitrosoalkylurea group, which is similar chemical structure, model intracranially transplanted Ehrlich's...