We consider the problem of estimating the graph associated with a binary Ising Markov random field. We describe a method based on 1-regularized logistic regression, in which the neighborhood of any given node is estimated by performing logistic regression subject to an 1-constraint. The method is analyzed under high-dimensional scaling in which both the number of nodes p and maximum neighborhoo...

For any positive integer n 2: 1 and for any prime number p let ep(n) be the exponent at which the prime p appears in the prime factor decomposition of nL In this note we prove the following; Theorem. Let p < q be two prime numbers, and let n > 1 be a positive integer such that pq I n. Then, (1) Inequality (1) was suggested by Balacenoiu at the First International Conference on Smarandache ::\ot...

Combined experimental and quantitative structure inter-activity relationship (QSIAR) computation methods were advanced in order to establish the structural and mechanistic influences that steroids and triterpenes, either as newly synthesized or naturally isolated products, have on human HT1080 mammalian cancer cells. The main Hansch structural indicators such as hydrophobicity (LogP), polarizab...

Analogous to the fraction unbound in microsomes (fu(mic)), fraction unbound in hepatocyte incubations (fu(hep)) is an important parameter in the prediction of intrinsic clearance and potential drug-drug interactions. A recent study by Austin et al. (Drug Metab Dispos 33:419-425, 2005) proposed a linear 1:1 relationship between the extent of binding to microsomes at 1 mg/ml and to hepatocytes at...

While the desire to use commodity parts in the communication architecture of a DSM multiprocessor offers advantages in cost and design time, the impact on application performance is unclear. We study this performance impact through detailed simulation, analytical modeling, and experiments on a flexible DSM prototype, using a range of parallel applications. We adapt the logP model to characteriz...

The pathogenesis of Alzheimer’s disease (AD) putatively involves a compromised blood-brain barrier (BBB). In particular, the importance of brain-to-blood transport of brain-derived metabolites across the BBB has gained increasing attention as a potential mechanism in the pathogenesis of neurodegenerative disorders such as AD, which is characterized by the aberrant polymerization and accumulatio...

Flash nanoprecipitation (FNP) can generate hydrophobic drug nanoparticles in ∼ 100 nm with a much higher drug loading (e.g., > 40 wt %) than traditional nanocarriers (e.g., < 20 wt %). This paper studies the effects of drug molecules on nanoparticle stability made via FNP and demonstrates that chemically bonding a drug compound (e.g., paclitaxel) with a cleavable hydrophobic moiety of organosil...

Infrared J and K photometry has been obtained of all red giants in the half square degree region of the LMC bar searched for variables using the MACHO database by Wood et al. (1999). The K–logP diagram shows the five distinct period–luminosity sequences which are also evident in the MACHO photometry. The K–logP plot allows identification of the Mira sequence from among the five observed sequenc...

We investigate a selected sample of Galactic classical Cepheids with available distance and reddening estimates in the framework of the theoretical scenario provided by pulsation models, computed with metal abundance Z=0.02, helium content in the range of Y =0.25 to 0.31, and various choices of the stellar mass and luminosity. After transforming the bolometric light curve of the fundamental mod...

We investigate a selected sample of Galactic classical Cepheids with available distance and reddening estimates in the framework of the theoretical scenario provided by pulsation models, computed with metal abundance Z=0.02, helium content in the range of Y =0.25 to 0.31, and various choices of the stellar mass and luminosity. After transforming the bolometric light curve of the fundamental mod...