In this paper, we introduce Linked Open Data (LOD) in the archaeological domain as a means to connect dispersed data sources and enable cross-querying. The technology behind design principles how LOD can be created published is described less-familiar researchers understand presented benefits drawbacks of LOD. Wikidata introduced an open knowledge hub for creation dissemination Different actors...

The emergence of Linked Open Data (LOD) enables data on the Web to have a well defined structure and thereby to represent and in‐ terlink information from different sources and application areas. This web of data is a complex socially created network, where concepts and rela‐ tions are connected in intricate ways, collectively forming a network of knowledge. These data are published in a decent...

OBJECTIVE Low-density lipoprotein (LDL) size is associated with vascular disease and with familial combined hyperlipidemia (FCHL). METHODS AND RESULTS We used logarithm of odds (lod) score and Bayesian Markov chain Monte Carlo (MCMC) linkage analysis methods to perform a 10-cM genome scan of LDL size, measured as peak particle diameter (PPD) and adjusted for age, sex, body mass index, and tri...

We conducted a genome scan using a 10-cM map to search for genes linked to type 2 diabetes in 691 individuals from a founder population, the Old Order Amish. We then saturated two regions on chromosomes 1 and 14 showing promising linkage signals with additional markers to produce a approximately 2-cM map for fine mapping. Analyses of both discrete traits (type 2 diabetes and the composite trait...

OBJECTIVE The C57BL/6 (B6) and 129 mouse inbred strains differ markedly in plasma HDL-cholesterol concentrations and atherosclerosis susceptibility after a high-fat diet consumption. To identify loci controlling these traits, we performed quantitative trait loci (QTL) analysis. METHODS AND RESULTS We fed a high-fat diet to 294 (B6x129S1/SvImJ)F2 females for 14 weeks, measured plasma HDL conce...

The activation of oxygenated hemoglobin (oxy-Hb) has been shown to be lacking in the prefrontal cortex (PFC) of patients with late-onset depression (LOD), in verbal fluency task (VFT)-related near-infrared spectroscopy (NIRS). In our previous studies, we have emphasized the connection between the lack of activation in the frontopolar cortex and social functioning disorder in patients with LOD. ...

Genome-wide variance components linkage analysis was performed on 4 latent factors underlying metabolic syndrome derived from 10 risk factors. The latent factors represent obesity and insulin, blood pressure, lipids and insulin, and central obesity. The metabolic syndrome factor scores were derived in 4 ethnic groups recruited in 3 Networks of the Family Blood Pressure Program: GENOA (blacks, H...

The quantification of single nucleotide polymorphism (SNP) allele frequencies in pooled DNA samples using real time PCR is a promising approach for large-scale diagnostics and genotyping. The limits of detection (LOD) and limits of quantification (LOQ) for mutant SNP alleles are of particular importance for determination of the working range, which, in the case of allele-specific real time PCR,...

Title of Document: GENETIC STUDIES OF STUTTERING IN A LARGE WEST AFRICAN FAMILY Bailey Levis, MS, 2006 Directed By: Associate Professor, Sarah Tishkoff, Department of Biology A large family of West African origin displaying persistent developmental stuttering was ascertained. This family contains 106 individuals, 45 of whom display the phenotype. A genome wide scan was conducted using 366 micro...

BACKGROUND Albuminuria and reduced glomerular filtration rate (GFR) are markers of renal dysfunction associated with hypertension. We performed genome-wide scans to detect loci impacting these parameters in 1251 African American (AAs) and 1129 European American (EAs) hypertensive siblings from the Hypertension Genetic Epidemiology Network study. METHODS GFR, estimated by the Modification of D...