Radiation may be used as adjuvant or primary therapy in a variety of tumors in the chest, abdomen and pelvis. Therapeutic radiation affects not only malignant tumors but also surrounding normal tissues. The risk of injury depends on the size, number and frequency of radiation fractions, volume of irradiated tissue, duration of treatment, and method of radiation delivery. Concomitant chemotherap...

Intestinal injury following abdominal radiation therapy or accidental exposure remains a significant clinical problem that can result in varying degrees of mucosal destruction such as ulceration, vascular sclerosis, intestinal wall fibrosis, loss of barrier function, and even lethal gut-derived sepsis. We determined the ability of a high-molecular-weight polyethylene glycol-based copolymer, PEG...

Patients presenting with pain after breast surgery were selected to undergo resection of intercostal neuromas. The patients had localized Tinel's signs at one or more intercostal nerves at the lateral chest wall with radiation in the distribution of the pain. Patients also responded to diagnostic injections of local anesthetic. The patients were felt to have pain not related to breast implants ...

Except for infectious diseases all the main occupational hazards affecting health workers are reviewed: accidents (explosions, fires, electrical accidents, and other sources of injury); radiation (stochastic and non-stochastic effects, protective measures, and personnel most at risk); exposure to noxious chemicals, whose effects may be either local (allergic eczema) or generalised (cancer, muta...

Clinical and experimental studies suggest that acute or chronic renal injury could occur after certain types of radiation accidents. Such renal injury could be life-threatening in its own right, could exacerbate other radiation injuries and could complicate the treatment of non-radiation injuries. The clinical experience with therapeutic bone marrow transplantation (BMT) indicates that acute re...

Knowledge of the mechanisms involved in the radiation response is critical for developing interventions to mitigate radiation-induced injury to normal tissues. Exposure to radiation leads to increased oxidative stress, DNA-damage, genomic instability and inflammation. The transcription factor CCAAT/enhancer binding protein delta (Cebpd; C/EBPδ is implicated in regulation of these same processes...

Background: Because implantation failure is more frequent, many methods have been suggested to improve the implantation; however, their results have been inconsistent. One of the most hopeful methods is local endometrial injury. To explore the possibility that local injury of the endometrium increases the incidence of implantation and pregnancy rate in the subsequent IVF cycle in patients havin...

We have studied conversion of marrow cells to skeletal muscle in cardiotoxin-injured anterior tibialis muscle in a green fluorescent protein (GFP) to C57BL/6 transplantation model and ascertained that total body irradiation (TBI) with establishment of chimerism is a critical factor. Local irradiation has little effect in lower doses and was detrimental at higher doses. Whole body (1000 cGy) wit...

* This work was supported in part by a grant from the U. S. Public Health Service. t Assigned to the California Institute of Technology by the National Cancer Institute. $ Contribution No. 1457. 1 Neel, J. V., in press. 2 Neel, J. V., Science, 110, 64 (1949). 3 Itano, H. A., and Pauling, L., Federation Proceedings, 8, 209 (1949). 4Pauling, L., Itano, H. A., Singer, S. J., and Wells, I. C., Scie...