Cervical cancer is an aggressive gynecological malignancy which can develop local invasion of the surrounding organs. In cases presenting locally advanced disease, the association of neoadjuvant chemo-irradiation might reduce the local invasion and might transform the patient into a candidate for a conservative surgical procedure. However, there are also patients who refuse any association of n...

The treelike structures of many organs, including the mammary gland, are generated by branching morphogenesis, a reiterative process of branch initiation and invasion from a preexisting epithelium. Using a micropatterning approach to control the initial three-dimensional structure of mouse mammary epithelial tubules in culture, combined with an algorithm to quantify the extent of branching, we ...

Bacterial infections and sepsis remain major causes of morbidity and mortality in intensive care units. The normal host response to infection is a complex process that serves to localise and control the invasion of microbes and to rep air injured tissue. Local inflammatory processes are regulated through the production of cytokines by macrophages. In some cases, mediator release exceeds the bou...

BACKGROUND Carcinomas of the salivary glands are uncommon heterogeneous tumors characterized by locoregional invasion and distant metastasis. Angiogenesis is a necessary condition for invasion and metastasis, and vascular endothelial growth factor (VEGF) is considered a prime mediator of this process. The relationship between VEGF and clinical outcome in cancers of diverse locations has been ex...