Atherosclerosis is a complex inflammatory disorder of the medium and large-sized arteries. Recent experiments demonstrated that atherosclerosis is a Th1 dominant autoimmune condition, whereas Th2 cells are rarely detected within the atherosclerotic lesions. Several studies have indicated that Th2 type cytokines could be effective in the reduction and stabilization of atherosclerotic plaque. The...

Nanoparticle-based delivery systems for cancer immunotherapies aim to improve the safety and efficacy of these treatments through local specialized antigen-presenting cells (APCs). Multifunctional mesoporous silica nanoparticles (MSNs), with their large surface areas, tunable particle pore sizes, spatially controlled functionalization, represent a safe versatile carrier system. In this study, w...

2007/Jul/02 Sensibility of quorum growth thresholds controlling local immune responses – p. 2007/Jul/02 Sensibility of quorum growth thresholds controlling local immune responses – p. 2/36 Motivation 2007/Jul/02 Sensibility of quorum growth thresholds controlling local immune responses – p. 3/36 Immune system Leukocytes (white blood cells) circulate in the blood Leukocytes are produced in the b...

To prove the existence of possible allergic reaction to local anaesthetic by the recommendations and experience of the current literature, an assortment or mosaic of complementary diagnostic tests is made by: anamnesis and a clinical picture and in vivo skin allergy tests - tests of the humeral and cellular immune response. Anamnesis and the clinical picture are mostly in metaphorical character...

Adjuvants play an important role in the efficacy of vaccines as the antigens become more and more purified. Indeed recombinant proteins or synthetic peptides are safer than crude inactivated micro-organism, but less immunogenic. This can be balanced by specific adjuvants. But there is no universal adjuvants and their action is not yet clear and rely on different mechanisms. Then, they must be a...

Antitumour activity is an effect attributed to probiotics and fermented foods. Here, the immune cells in mammary glands and cytokine concentration in serum were analyzed using mice fed with milk fermented by Lactobacillus helveticus R389 or L89 (proteolytic-deficient variant), injected or not with breast tumour cells. Mice were fed 7 days with fermented milk, injected with breast tumour cells a...

Background: Macrophage immune responses are affected by the secretory proteins of Mycobacterium tuberculosis (Mtb). This study aimed to examine the immune responses of macrophages to Mtb secretory antigens, namely ESAT-6, CFP-10, and ESAT-6/CFP-10.Methods: THP-1 cells (a human monocytic cell line) were cultured and differentiated to macrophages by phorbol 12-myristate 13-acetate. The cytotoxici...

CONTEXT Child emotional maltreatment can result in lasting immune dysregulation that may be heightened in the context of more recent life stress. Basal cell carcinoma (BCC) is the most common skin cancer, and the immune system plays a prominent role in tumor appearance and progression. OBJECTIVE To address associations among recent severe life events, childhood parental emotional maltreatment...

background human immunodeficiency virus (hiv) infected patients are also frequently exposed to the hepatitis b virus (hbv), due to the common routes of transmission, therefore, prevention of hepatitis b results in decreased complications of the disease. objectives since the immune response of hiv patients to hepatitis b vaccination is less robust than that found in healthy individuals, this stu...