BACKGROUND The rise in inspiratory flow is important during patient-triggered ventilation. Many ventilators incorporate a function to control the time to reach the targeted airway pressure (inspiratory rise time). However, it has not been clarified how inspiratory rise time affects inspiratory work load under various ventilator settings. In a bench study we investigated the effect of inspirator...

UNLABELLED Human norovirus (NoV) is the most frequent cause of epidemic nonbacterial acute gastroenteritis worldwide. We investigated the impact of nonthermal or cold atmospheric pressure plasma (CAPP) on the inactivation of a clinical human outbreak NoV, GII.4. Three different dilutions of a NoV-positive stool sample were prepared and subsequently treated with CAPP for various lengths of time,...

Transgenic animal models have provided a vital insight into the pathogenesis of cardiovascular disease, but functional cardiac assessment is often limited by high heart rates and small heart size. We hypothesized that in the presence of concentric left ventricular (LV) hypertrophy (LVH), load-sensitive measures of contractility may be misinterpreted as overestimating global cardiac function, be...

We have studied the kinetics of mixed venous C02 pressure (Pi-,co2) at constant work rates of 300, 450 and 600 kpmlmin (Yano, 1986). The PVco, increased at the onset of exercise, and reached a steady state at 300 and 450 kpmlmin. However, at 600 kpmlmin, the PVco2 indicated a relatively high steady state in comparison with those at other work rates, and decreased after 5 min of exercise. This o...

BACKGROUND AND AIM To assess blood pressure (BP) load in a population of treated hypertensive patients. METHODS The study group consisted of 137 hypertensive adults, including 75 (54.75%) men and 62 (45.25%) women, with either formerly or newly diagnosed hypertension based on office BP measurements. The median age in the whole study group was 52 years (47 and 56 years among men and women, res...

BACKGROUND Although some genes associated with increased risk of Alzheimer Disease (AD) have been identified, few data exist related to gene/gene and gene/environment risk of AD. The purpose of this pilot study was to explore gene/gene and gene/environment associations in AD and to obtain data for sample size estimates for larger, more definitive studies of AD. METHODS The effect of gene/gene...

abstract: the present study deals with the buckling analysis of the laminated composite truncated conical sandwich shells with flexible core subjected to combined axial compressive load and external pressure. higher order governing equations of the motion are presented for conical composite sandwich shells, where they are derived from the hamilton principle. then, by the use of improved higher-...

Maximum elastance is an experimentally validated, load-independent systolic function index stemming from the time-varying elastance paradigm that decoupled extrinsic load from (intrinsic) contractility. Although Doppler echocardiography is the preferred method of diastolic function (DF) assessment, all echo-derived indexes are load dependent, and no invasive or noninvasive load-independent inde...

in the current engineering practices, buildings are commonly designed for an effective lifetime of 50 years. this lifetime can increase the cost of buildings with short lifetimes and can reduce the safety level of buildings with large lifetimes. in this paper, a “service-life factor” has been defined. applying this factor into the nominal values of live, earthquake, wind, and snow loads, the ef...

Effects of Western diet and lifestyle factors resulting in hypertension are known, however, the effects of lifestyle on blood pressure variability measured by ambulatory blood pressure monitoring are not sufficiently well known. In the present case, it has been observed that Western diet, sedentary behavior and mental load in a subject with normal blood pressures were associated with blood pres...