NoSQL databases store a huge amount of data generated by modern web applications. To improve scalability, a database is partitioned and distributed among the different nodes called as a scale out. However, this scale out feature of the NoSQL database is oblivious to the data access pattern of the web applications, which results in poorly distributed data across all the nodes. Therefore, the cos...

Mutations are the substrate of cancer. Yet, little is known about the degree and nature of mutations in tumors because measurement of mutation load in tumors and normal tissues was generally not possible until the advent of transgenic mouse mutation detection systems. Herein, we present the first analysis of mutation frequency and pattern in thymic tumors from a mouse model of Li-Fraumeni syndr...

The picture that emerges from phylogenetic gene content reconstructions is that genomes evolve in a dynamic pattern of rapid expansion and gradual streamlining. Ancestral organisms have been estimated to possess remarkably rich gene complements, although gene loss is a driving force in subsequent lineage adaptation and diversification. Here, we study genome dynamics in a model of virtual cells ...

Building model calibration is critical in bringing simulated energy use closer to the actual consumption. This paper presents a novel, automated model calibration approach that uses logic linking parameter tuning with bias pattern recognition to overcome some of the disadvantages associated with traditional calibration processes. The pattern-based process contains four key steps: (1) running th...

Accurately identifying the peak value of impact load acting on helicopter structure during weapon launch is great significance to design and finalization pylons. Firstly, a method standardized preprocessing signal proposed by analyzing vibration response characteristics load. Then, test model pylon designed, position strain gauge determined; static calibration ground are carried out model. Next...