Current practice in Quantitative Structure Activity Relationship (QSAR) methods usually involves generating a great number of chemical descriptors and then cutting them back with variable selection techniques. Variable selection is an effective method to reduce the dimensionality but may discard some valuable information. This paper introduces Locally Linear Embedding (LLE), a local non-linear ...

LLE Review, Volume 72 161 The Laboratory for Laser Energetics (LLE) with its OMEGA facility is part of the national laser-fusion effort within the U.S. Department of Energy and has as its main mission direct-drive laser-fusion research in support of the upcoming National Ignition Facility (NIF) at the Lawrence Livermore National Laboratory (LLNL). The upgraded OMEGA laser system has been in ope...

LLE Review, Volume 69 1 The ultimate goal of the LLE uniformity program is to reduce the rms laser-irradiation nonuniformity to the 1%–2% level, which is required for cryogenic implosion experiments on OMEGA. The combination of distributed phase plates (DPP’s), two-dimensional (2-D) smoothing by spectral dispersion (SSD), polarization wedges, and beam overlap should be sufficient to reach this ...

In this report, the student presents her study on a multivariate visualization task. Specifically, the student would like to learn the use of Locally Linear Embedding (LLE) for visualization. While the experiment is using Wisconsin Breast Cancer dataset, the method is more generally applicable to other high-dimensional data as well. Three experiments were run to visualize the dataset. The three...

Major advances in laser technology at LLE have included the demonstration of high-efficiency frequency doubling and tripling of fusion lasers1 and the development of short-pulse, chirped-pulse-amplification (CPA) lasers2 These technologies were combined a few years ago with the demonstration of 75% efficient frequency doubling of 1.6-ps laser pulses on the CPA T~ (table-top terawatt) system at ...

Démocratie et écologie ne sont pas seulement conciliables. La philosophe Joëlle Zask les tient pour indissociables dans l’expérience d’être au monde en pleine responsabilité.

background: increasing frame rate is a challenging issue for better interpretation of medical images and diagnosis based on tracking the small transient motions of myocardium and valves in real time visualization. methods: in this paper, manifold learning algorithm is applied to extract the nonlinear embedded information about echocardiography images from the consecutive images in two dimension...

Background:Extraction of drugs is one of the biggest concerns and the most important part of preparation and determination in forensic medicine. The lack of an easy, efficient and fast extraction method is the most important and most difficult problem despite the development of forensic centers and their being equipped with new diagnostic devices. In the present study, a comparison was conducte...