INTRODUCTION The present study objective was to evaluate the incidence of methotrexate (MTX)-specific liver lesions from the analysis of a liver biopsy of inflammatory arthritis patients with elevated liver enzymes. METHODS A case-control study was performed with 1,571 arthritis patients on long-term low-dose MTX therapy. Results of liver biopsy were analyzed in 41 patients with elevated live...

Abstract Leucine-rich α-2 glycoprotein (LRG), one of the acute phase proteins mainly produced by liver, similar to C-reactive protein, has been recognized as an inflammatory biomarker for rheumatoid arthritis and bowel diseases. We recently demonstrated that LRG was also increased in sera psoriasis patients correlated well with disease activity a sensitivity specificity much higher than protein...

Morphological features of lesions conforming to the description of solitary necrotic nodules of the liver were compared with liver haemangiomata and necrotic tumour metastases in the liver. An origin in haemangiomata is confirmed for most of the lesions studied, although the necrotic nodule may represent the end stage of a variety of lesions. These lesions are usually benign, although necrotic ...

intra-tumoral bleeding, rupture and thrombosis are common complications of hemangioma but spontaneous and self limited rupture and fever is a very rare presentation of hemangioma. this report is about a 38-year-old woman with sever abdominal pain and high fever came for evaluation. in us she had a liver mass of about 15 cm in left lobe with possibility of being hemangioma and, ct scan and mri c...

BACKGROUND Silibinin exerts hepatoprotective, anti-inflammatory and anti-fibrotic effects. Several pre-clinical studies have shown anti-tumoral activity of silibinin in breast cancer cell lines. CASE REPORT We present the case of a heavily pre-treated breast cancer patient with extensive liver infiltration. The patient presented with progressive liver failure despite several chemotherapy trea...

Purpose To report the clinical and histopathological findings of atypical intravitreal growth of a retinoblastoma with a multi-branching configuration. Observations A 7-month-old boy was referred to our hospital due to leukocoria in the right eye. Ophthalmic examinations identified multi-branching vessels surrounded by diaphanous tissue behind the lens in the right eye. Imaging modalities sho...

Liver radioembolization is a treatment option for unresectable liver cancers, performed by infusion of 90Y or 166Ho loaded spheres in the hepatic artery. As tumoral cells are mainly perfused via artery unlike lobules, twofold tumor to normal dose ratio commonly obtained. To improve cell killing while preserving co-infusion arterial vasoconstrictor has been proposed but with limited success: buf...