In MRI, the coherence lifetime T2 is sensitive to the magnetic environment imposed by tissue microstructure and biochemistry in vivo. Here we explore the possibility that the use of T2 relaxometry may provide information complementary to that provided by diffusion tensor imaging (DTI) in ageing of healthy controls (HC), Alzheimer's disease (AD) and mild cognitive impairment (MCI). T2 and diffus...

Abstract Background Hepatocellular carcinoma (HCC) is the fifth most frequent cancer on world. Fat accumulation within hepatocytes known as hepatic steatosis. In recent years, research has found that people with non-alcoholic fatty liver disease have a higher chance of developing HCC. The LI-RADS ® (Liver Imaging Reporting and Data System) was created to facilitate consistent reporting imaging ...

A 52-year-old female without comorbidities presented with dull, aching pain in the right upper quadrant associated with nausea, but not fever, jaundice, anorexia, or abdominal distension. Examination showed tachycardia and mild tenderness in the right upper quadrant. Investigations revealed a normal hemogram with preserved liver function, renal function, and normal pancreatic enzyme levels. Abd...

PURPOSE To develop a model-based reconstruction technique for T2 mapping based on multi-echo spin-echo MRI sequences with highly undersampled Cartesian data encoding. MATERIALS AND METHODS The proposed technique relies on a nonlinear inverse reconstruction algorithm which directly estimates a T2 and spin-density map from a train of undersampled spin echoes. The method is applicable to acquisi...

Correspondence Dr. Arthur P. Wunderlich Klinik für Diagnostische und Interventionelle Radiologie, Universitätsklinikum Ulm Albert-Einstein-Allee 23 D-89070 Ulm Germany Tel.: ++ 49/7 31/500610 86 Fax: ++ 49/7 31/500611 08 [email protected] Pathophysiology of iron overload ▼ Normal iron content plays an important role in the physiological processes of the human body. A disturbance to t...

BACKGROUND MRI has been proposed for non-invasive detection and quantification of liver iron content, but has not been validated as a reproducible and sensitive method, especially in patients with mild iron overload. We aimed to assess the accuracy of a simple, rapid, and easy to implement MRI procedure to detect and quantify hepatic iron stores. METHODS Of 191 patients recruited, 17 were exc...

BACKGROUND Acute subarachnoid hemorrhage (SAH) has traditionally been diagnosed by computed tomography (CT); however, fluid-attenuated inversion recovery (FLAIR) is a magnetic resonance imaging (MRI) modality currently used to detect acute SAH. CT is insensitive in the detection of subacute or chronic SAH. The purpose of this study was to compare 4 MRI pulse sequences and CT in the detection of...

Ultrasound-triggered phase transition sensitive nanodroplets with multimodal imaging functionality were prepared via premix Shirasu porous glass (SPG) membrane emulsification method. The nanodroplets with fluorescence dye DiR and SPIO nanoparticles (DiR-SPIO-NDs) had a polymer shell and a liquid perfluoropentane (PFP) core. The as-formed DiR-SPIO-NDs have a uniform size of 385 ± 5.0 nm with PDI...

A modern multi-functional drug carrier is critically needed to improve the efficacy of image-guided catheter-directed approaches for the treatment of hepatic malignancies. For this purpose, a nanocomposite microsphere platform was developed for selective intra-arterial transcatheter drug delivery to liver tumors. In our study, continuous microfluidic methods were used to fabricate drug-loaded m...