background: despite the prevalence of non-alcoholic fatty liver disease (nafld) and non-alcoholic steatohepatitis (nash), no treatment has been proven to be effective in these common diseases. although many studies have shown that lifestyle modifications such as increasing physical activities and exercise could be effective in the treatment of these common diseases, the optimal strategy is stil...

background there are several studies in the literature investigating factors which can induce non-alcoholic fatty liver disease (nafld) in different populations. however, the existing literature lacks powerful studies addressing the factors which may predict the severity of nafld. objectives in the current study, we aimed to evaluate factors independently associated with liver echogenicity in a...

background: nowadays, drug and observation are advised to patients with lymphocytic hypophysitis and in some cases with nonfunctioning pituitary macoadenoma, instead of surgery. case presentation: in this article, we report a woman with nonfunctional pituitary macroadenoma and panhypopitutarism and negative criteria for lymphocytic hypophysitis associated with increased liver enzymes. after thr...

introduction: cisplatin is an antineoplastic drug, which is widely used for the treatment of solid tumors. however, its clinical usage is limited because of its side effects such as hepatotoxicity. this study aimed to identify toxic effects of cisplatin on hepatocytes of rats. methods: a total of 45 adult sprague dawley rats weighing 200±30 g were randomly divided into experimental (n=30) and c...

doxorubicin (dox) is an anthracycline antibiotic that has been used for a long time in therapy of an array of human malignancies either alone or in combination with other cytotoxic agents. the dose-dependent cardiotoxicity of dox significantly limits its anticancer efficacies. oxidative stress caused by enhanced production of reactive oxygen species is an important contributor to dox mitochondr...

background: mesenchymal stem cells (mscs) have been recently received increasing attention for cell-based therapy, especially in regenerative medicine. however, the low survival rate of these cells restricts their therapeutic applications. it is hypothesized that autophagy might play an important role in cellular homeostasis and survival. this study aims to investigate the regenerative potentia...

liver functional tests due to inflammatory process which induced by cholecystitis might changed and some clinicians suggested that these changes might help us to stone prediction in common bile ducts and decrease hazards of performing ercp and other invasive procedures. present study was performed for assessment of role of liver functional test in diagnosis of common bile duct stone in patients...

following failure of systemic chemotherapy, transarterial chemoembolization (tace) is an available method to control unresectable liver metastases from colorectal carcinoma (crc). the aim of present study was to evaluate the efficacy of chemoembolization for inoperable metastatic liver lesions from crc. forty-five crc patients with liver metastases resistant to systemic chemotherapy were enroll...

this research aims  to monitor the trace elements content (cr, cu, pb, cd, ag, al, mn, mg, zn and fe) in the tissues of the muscle and liver of silver carp (h. molitrix ) and stone moroko (p. parva) from zarivar wetland in western iran. this research was cross-sectional. the research specimen  was fish caught from zarivar wetland. metal concentration analysis was carried out utilizing an  icp. ...

in india, a number of medicinal plants and their formulations are used to cure hepatic disorders in traditional systems of medicine. no systemic study has been done on protective effect of cucumis trigonus roxb. (cucurbitaceae) to treat hepatic diseases. protective action of c. trigonus fruit extracts was evaluated in this study in animal model of hepatotoxicity, which was induced by carbon tet...