1.0 Introduction Erlich is credited with the first liver aspiration in 1883 and subsequently the first percutaneous liver biopsy for diagnostic purposes was reported in 1923. The technique has been modified since then, and over the past 50 years it has become a central investigation of hepatic disease. The low mortality (0.01–0.17%) and the relatively low morbidity of this procedure have meant ...

Fibrosis is an intrinsic response to chronic injury, that elicits excess deposition of matrix compounds and scarring, which ultimately alters liver structure and function. Liver biopsy has long been the gold standard for assessing the degree of liver fibrosis. Due to liver biopsy invasiveness, specialists and patients favor alternative non-invasive tests for fibrosis staging. In recent years, m...

results 100 patients with cirrhosis with a male to female ratio of 63:37 and a mean age of 44.4 ± 15 years were enrolled in the study. median igf-1 was 92.95 ± 91.51 ng/ml. 14 patients (14%) had igf-1 within normal limits while 86 patients (86%) had abnormal igf-1 levels. in all patients the correlation coefficient between igf-1 and meld was -0.317 (p = 0.001) and 0.478 between igf-1 and child-...

After several complications following percutaneous liver biopsy in patients with sickle cell disease, we reviewed our experience. We examined 14 patients with sickle cell disease who underwent a percutaneous liver biopsy. Clinicopathologic findings were correlated with outcome. Of 14 patients, 5 (36%) suffered serious hemorrhage; 4 died (80%; 28% of all patients). None of the 9 patients without...