نتایج جستجو برای: liposomes organelles

تعداد نتایج: 28186  

Journal: :Current Opinion in Cell Biology 2014

Journal: :Microbiology and Molecular Biology Reviews 2014

2007
Arcadio Chonn Pieter R. Cullis

Several agents have been shown to prolong the circulation lifetime of liposomes. These agents, such as ganglioside GM1 or phosphatidylethanolaminederivatives of monomethoxypolyethyleneglycols, provide insight into the mechanism(s) by which liposomes are cleared from the circulation. It is suggested here that the primary mechanism by which these molecules alter the biodistribution of liposomes i...

2013
Alice Beebyaanda Nongonierma Magdalena Abrlova Kieran Noel Kilcawley

A concentrated form of cell free extract (CFE) derived from attenuated Lactococcus lactis supsb. lactis 303 CFE was encapsulated in liposomes prepared from two different proliposome preparations (Prolipo Duo and Prolipo S) using microfluidization. Entrapment efficiencies of 19.7 % (Prolipo S) and 14.0 % (Prolipo Duo) were achieved and the preparations mixed in the ratio 4 (Prolipo Duo):1 (Proli...

2018
Eiji Yuba Tomohiro Osaki Misato Ono Shinjae Park Atsushi Harada Masamichi Yamashita Kazuo Azuma Takeshi Tsuka Norihiko Ito Tomohiro Imagawa Yoshiharu Okamoto

Cancer chemotherapeutic systems with high antitumor effects and less adverse effects are eagerly desired. Here, a pH-sensitive delivery system for bleomycin (BLM) was developed using egg yolk phosphatidylcholine liposomes modified with poly(ethylene glycol)-lipid (PEG-PE) for long circulation in the bloodstream and 2-carboxycyclohexane-1-carboxylated polyglycidol-having distearoyl phosphatidyle...

Journal: :Antimicrobial agents and chemotherapy 1979
H Yamaguchi K Iwata

The specific affinity for membrane lipids and the membrane selectivity of three imidazole derivatives, clotrimazole, miconazole, and econazole, were studied using various types of liposomes with respect to the lecithin fatty acyl group composition and the liposome content and composition of sterol as membrane models. The sensitivity of liposomes to these drugs was primarily dependent upon the l...

Journal: :Biomaterials 2010
Eiji Yuba Chie Kojima Atsushi Harada Tana Shinobu Watarai Kenji Kono

By modification of liposomes with poly(glycidol) derivatives such as succinylated poly(glycidol) and 3-methylglutarylated poly(glycidol), we have developed functional liposomes that generate fusion ability at mildly acidic pH. We investigated the feasibility of these polymer-modified liposomes as a carrier of antigenic proteins for induction of cellular immunity. These pH-sensitive fusogenic li...

2001
Dana V. Devine

We have studied the complement-activating properties of liposomes. We show that surface charge is a key determinant of complement-activating liposomes. The nature of the charge, whether negative or positive, appears to dictate which pathway of the complement system is activated. Phosphatidylcho1ine:cholesterol (PC:CHOL, 55:45 mol/mol) iposomes were made to exhibit a positive or negative surface...

Journal: :Human reproduction 1997
R Bajoria S R Sooranna S F Contractor

We evaluated the mechanism of uptake of carboxyfluorescein-containing small unilamellar liposomes of different surface charge by trophoblast cells in culture. Carboxyfluorescein-encapsulated neutral liposomes were prepared by using equimolar concentrations of lecithin and cholesterol. Anionic and cationic liposomes were prepared by adding dicetylphosphate and stearylamine. Trophoblast cells fro...

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