Pellucid marginal degeneration (PMD) is a rare progressive condition resulting in inferior corneal thinning and astigmatism. Alongside keratoconus and keratoglobus, it is considered one of noninflammatory corneal ectasias. The focus of corneal thinning is greatest inferiorly resulting in diminished visual acuity and overall reduction in visual quality. Traditional methods of treatment or diseas...

BACKGROUND We describe a modified method for deepitheliazation prior to corneal cross linking (CXL). The technique may overcome the current corneal pachymetric limitation parameter (over 400 microns) that is necessary for the safety of the procedure without affecting the overall benefits. METHODS In a series of two patients, with inferior topographic steepening and regional thinning (less tha...

A 32-year-old female patient with progressive keratoconus in her right eye was treated with simultaneous customized photoreactive keratoctomy (PRK) and corneal cross-linking (CXL) with riboflavin and Ultraviolet A (UVA) irradiation. Ten days after the procedure, the patient was presented with foreign body sensation, mild ring-shaped corneal infiltration with vascularization at the limbus and Tr...

Aim of the Study: Using anterior segment optical coherence tomography (AS-OCT) to compare depth corneal demarcation line (DL) after collagen cross-linking (CXL) with subtotal versus customized epithelium debridement. Design: Prospective multi centric case-control study. Materials and Methods: The study enrolled 18 patients bilateral progressive keratoconus. Both eyes treated by CXL using 3 mW/c...

Corneal collagen cross-linking (CXL) is a successful technique used to slow the progression of corneal ectatic disease, mainly keratoconus. It is able to achieve this aim with a single application of vitamin B2 (riboflavin) and ultraviolet-A light to the corneal stroma where it results in crosslinks to form between the collagen fibres, resulting in corneal stiffening. We describe the different ...

Collagen cross-linking (CXL) is being offered to a growing number of keratoconic patients worldwide for prevention of disease progression, with an overall success rate that exceeds 90% of the treated eyes.1,2 However, some patients do continue to progress after CXL and may need to undergo keratoplasty. Deep anterior lamellar keratoplasty (DALK) has become the preferred technique by an increasin...

Objective: To compare the effect of rapid and conventional methods of corneal collagen cross linking (CXL) on visual acuity (VA) and corneal parameters in Keratoconus. Study Design: Randomized control trial. Place and Duration of Study: Armed Forces Institute of Ophthalmology, Feb 2012 to Apr 2013. Patients and Method: Thirty patients, fifteen in each group, were randomized by non probability c...

Purpose. To report the visual, refractive, and corneal topography and wavefront aberration results of accelerated corneal cross-linking (CXL) during a 24-month follow-up. Methods. Forty-seven eyes underwent riboflavin-ultraviolet A-induced accelerated CXL treatment (30 mW/cm2 with a total dose of 7.2 joules/cm2). Uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA)...

BACKGROUND Corneal collagen cross-linking with riboflavin, also known as collagen cross-linking (CXL), involves the application of riboflavin solution to the eye that is activated by illumination with ultraviolet A (UVA) light. We survey here the topographic corneal changes one year after CXL in patients with corneal keratoconus. MATERIALS AND METHODS This prospective randomized clinical tria...

PURPOSE To report the development of posterior linear stromal haze after simultaneous photorefractive keratectomy (PRK) followed by corneal collagen cross-linking (CXL). METHODS Combined simultaneous customized PRK followed by corneal collagen cross-linking was performed in 23 patients (28 eyes) with keratoconus. Corneas were examined biomicroscopically and by means of confocal microscopy bef...