Relationships between bridge damage and the resulting loss of functionality of the bridge are critical to assessing the impact of an earthquake event on the performance of the transportation network. This study addresses this data need by use of a Web-based survey of central and southeastern U.S. Department of Transportation bridge inspectors and officials. Results of the 28 responses are analy...

Most aircraft fleets nowadays are operating under the concept of damage tolerance, which requires an aircraft to have sufficient residual strength in the presence of damage in one of its principal structural elements (PSE) during the interval of service inspections. The residual strength however is significantly reduced due to multi site damage (MSD). In the present paper, a probabilistic frame...

DNA damage signaling and repair take place in a chromatin context. Consequently, chromatin-modifying enzymes, including adenosine triphosphate-dependent chromatin remodeling enzymes, play an important role in the management of DNA double-strand breaks (DSBs). Here, we show that the p400 ATPase is required for DNA repair by homologous recombination (HR). Indeed, although p400 is not required for...

The ICP0 protein of herpes simplex virus type 1 is an E3 ubiquitin ligase and transactivator required for the efficient switch between latent and lytic infection. As DNA damaging treatments are known to reactivate latent virus, we wished to explore whether ICP0 modulates the cellular response to DNA damage. We report that ICP0 prevents accumulation of repair factors at cellular damage sites, ac...

DNA damage response (DDR) networks have long been noted to be implicated in cell death induced via ionizing radiation (1). These DNA damage sensing and signaling pathways establish control through cell cycle checkpoints, cellular senescence, and apoptosis (2). When functioning properly, DDR networks act as a barrier against tumor growth while maintaining genome integrity. New discoveries have u...

In this study, we investigated whether DNA double-strand breaks (DSBs) contribute to the pathogenesis of chronic obstructive pulmonary disease (COPD). We immunofluorescence-stained lung tissue samples obtained from COPD patients, asymptomatic smokers and nonsmokers for markers of DSBs. The numbers of DSB foci (phosphorylated histone 2AX (γH2AX), phosphorylated ATM (ataxia telangiectasia mutated...

Revision of orthopedic surgeries is often expensive and involves higher risk from complications. Since most total joint replacement devices use a polyethylene bearing, which serves as a weak link, the assessment of damage to the liner due to in vivo exposure is very important. The failures often are due to excessive polyethylene wear. The glenoid liners are complex and hemispherical in shape an...

The enzyme Poly(ADP-ribose) polymerase 1 (PARP1) plays a very important role in the DNA damage response, but its role in numerous aspects is not fully understood. We recently showed that in the absence of DNA damage, PARP1 regulates the expression of the chromatin-modifying enzyme EZH2. Work from other groups has shown that EZH2 participates in the DNA damage response. These combined data sugge...

UNLABELLED Many cancers display both structural (s-CIN) and numerical (w-CIN) chromosomal instabilities. Defective chromosome segregation during mitosis has been shown to cause DNA damage that induces structural rearrangements of chromosomes (s-CIN). In contrast, whether DNA damage can disrupt mitotic processes to generate whole chromosomal instability (w-CIN) is unknown. Here, we show that act...

The present work describes a multiscale methodology which has been developed for modeling of impact damage in the laminated composite structures. The methodology employs the High Fidelity Generalized Method of Cells (HFGMC) micromechanical model for the prediction of the local stress and strain fields, within the representative unit cell of the unidirectional composite material. The Mixed Mode ...