We evaluate the virial coefficients Bk for k ≤ 10 for hard spheres in dimensions D = 2, · · · , 8. Virial coefficients with k even are found to be negative when D ≥ 5. This provides strong evidence that the leading singularity for the virial series lies away from the positive real axis when D ≥ 5. Further analysis provides evidence that negative virial coefficients will be seen for some k > 10 ...