Impairment of the ubiquitin-proteasome system (UPS) has long been considered an attractive hypothesis to explain the selective dysfunction and death of neurons in polyglutamine disorders such as Huntington's disease (HD). The fact that inclusion bodies in HD mouse models and patient brains are rich in ubiquitin and proteasome components suggests that the UPS may be hindered directly or indirect...

Petri nets are commonly used to represent concurrent systems. However, they lack support for modelling and analysing system families, like variants of controllers, different variations a process model, or the possible configurations flexible assembly line. To facilitate potentially large collections similar systems, in this paper, we enrich with variability mechanisms based on product line engi...

In eukaryotes, regulated protein turnover is required during many cellular processes, including defense against pathogens. Ubiquitination and degradation of ubiquitinated proteins via the ubiquitin-proteasome system (UPS) is the main pathway for the turnover of intracellular proteins in eukaryotes. The extensive utilization of the UPS in host cells makes it an ideal pivot for the manipulation o...

The presence of endoplasmic reticulum (ER) stress and impaired ubiquitin-proteasome system (UPS) activity has been independently implicated in the pathophysiology of conformational diseases. Here, we reveal a link between ER stress and the functionality of the UPS. Treatment of cells with different ER stressors delayed the degradation of an ER reporter substrate and caused a subtle but consiste...

Sustainability-oriented start-ups are fundamental to developing solutions for, and fostering, a societal transition towards low carbon society. In this context, social impact accelerators (SIAs) organizations specializing in accelerating the progress of sustainability-oriented start-ups. order design their accelerator elements (e.g., training, coaching, funding) effectively, SIAs must be aware ...