Nanotechnology can be an important tool to improve the permeability of some drugs for the blood-brain barrier. In this work we created a new system to enter the brain by functionalizing solid lipid nanoparticles with apolipoprotein E, aiming to enhance their binding to low-density lipoprotein receptors on the blood-brain barrier endothelial cells. Solid lipid nanoparticles were successfully fun...

The impermeant nature of the intestinal barrier is maintained by tight junctions (TJs) formed between adjacent intestinal epithelial cells. Disruption of TJs and loss of barrier function are associated with a number of gastrointestinal diseases, including neonatal necrotizing enterocolitis (NEC), the leading cause of death from gastrointestinal diseases in preterm infants. Human milk is protect...

please cite this article as: ordobazari m, naqavi al-hosseini aa, zafarmand h. a novel approach for craniofacial symmetry evaluation: using the midsagittal reference line drawn from “crista gali” with nhp technique. novel biomed 2013;1(2):48-53. background and objective: the purpose of this study was the determination of midsagittal reference line (msl) for craniofacial asymmetry assessment by ...

Bacteroides fragilis is a member of the normal colonic microflora of most mammals and is the most commonly isolated anaerobe from human clinical specimens. Some strains produce a toxin (fragilysin, a zinc-metalloproteinase) implicated as a cause of diarrheal disease in farm animals and humans. Studies in our laboratory confirm that the proteolytic activity of this toxin is responsible for the f...

according to statistics released by agricultural insurance fund (aif) less than 4 million acres out of 90 million acres has been covered by pastures insurance. this observation along with several facts motivated authors to study possible barriers which pastures insurance has been encountered in practice. the research population included all the experts in agricultural insurance fund. small popu...

In this paper, we first remodel the line coverage as a 1D discrete problem with co-linear targets. Then, an orderbased greedy algorithm, called OGA, is proposed to solve the problem optimally. It will be shown that the existing order in the 1D modeling, and especially the resulted Markov property of the selected sensors can help design greedy algorithms such as OGA. These algorithms demonstrate...

t-shape profile barriers are one of the most successful barriers among many different profiles. it has been shown that using welled diffusers on the top of t-shaped barriers makes a reactive barrier that shows better performance than that of any other used profile barriers compared with their equivalent absorbent barrier. the contribution of the top surface of reactive t-profile barriers to the...