Cancer cells exhibit a variety of features indicative of atypical nuclei. However, the molecular mechanisms underlying these phenomena remain to be elucidated. The linker of nucleoskeleton and cytoskeleton (LINC) complex, a nuclear envelope protein complex consisting mainly of the SUN and nesprin proteins, connects nuclear lamina and cytoskeletal filaments and helps to regulate the size and sha...

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Computer system batch schedulers typically require information from the user upon job submission, including a runtime estimate. Inaccuracy of these runtime estimates, relative to the actual runtime of the job, has been well documented and is a perennial problem mentioned in the job scheduling literature. Typically users provide these estimates under circumstances where their job will be killed ...

Vinculin, a mechanotransducer associated with adherens junctions (AJ) and focal adhesions (FA), plays central role in force transmission through cell-cell cell-substratum contacts. Previously, we generated mice conditional knockout (KO) of vinculin the skin, which results loss bulge stem cell (BuSC) quiescence, promotes continual cycling hair follicles. Surprisingly, found that AJs KO cells are...

As of 2014, cardiovascular disease (CVD) was listed as the underlying cause for 1 of every 3 deaths in the United States. Many forms of CVD have a strong genetic component, and the number of causal genes elucidated greatly depends on the type of CVD under study. Understanding the molecular basis of CVD can guide medical decisions of the practitioner, patient, and family members. Currently, gene...

The nuclear envelope segregates the nucleoplasm from the cytoplasm and is a key feature of eukaryotic cells. Nuclear envelope architecture is comprised of two concentric membrane shells which fuse at multiple sites and yet maintain a uniform separation of 30-50 nm over the rest of the membrane. Studies have revealed the roles for numerous nuclear proteins in forming and maintaining the architec...