Neuropeptide Y (NPY) is an inhibitory neuromodulator expressed abundantly in the central nervous system that is suspected of being an endogenous antiepileptic agent that can control propagation of limbic seizures. Electrophysiological and pharmacological data suggest that these actions of NPY are mediated by G protein-coupled NPY Y2 and NPY Y5 receptors. To determine whether the NPY Y5 receptor...

The early pathophysiologic study showed increasing evidence that autoimmunity is implicated in the pathogenesis of neuromyotonia. Antibodies to voltage gated potassium channel were detected in the serum of patients who had peripherical nerves hyperexcitability and also Morvan’s disease or limbic encephalitis. These discoveries offered new approaches to treatments. Recently, antibodies previousl...

Tinnitus, the most common auditory disorder, affects about 40 million people in the United States alone, and its incidence is rising due to an aging population and increasing noise exposure. Although several approaches for the alleviation of tinnitus exist, there is as of yet no cure. The present article proposes a testable model for tinnitus that is grounded in recent findings from human imagi...

Ann Kelley was a scientific pioneer in reward neuroscience. Her many notable discoveries included demonstrations of accumbens/striatal circuitry roles in eating behavior and in food reward, explorations of limbic interactions with hypothalamic regulatory circuits, and additional interactions of motivation circuits with learning functions. Ann Kelley's accomplishments inspired other researchers ...

The affective dimension of pain is made up of feelings of unpleasantness and emotions associated with future implications, termed secondary affect. Experimental and clinical studies show serial interactions between pain sensation intensity, pain unpleasantness, and secondary affect. These pain dimensions and their interactions relate to a central network of brain structures that processes nocic...

The early pathophysiologic study showed increasing evidence that autoimmunity is implicated in the pathogenesis of neuromyotonia. Antibodies to voltage gated potassium channel were detected in the serum of patients who had peripherical nerves hyperexcitability and also Morvan’s disease or limbic encephalitis. These discoveries offered new approaches to treatments. Recently, antibodies previousl...

The early pathophysiologic study showed increasing evidence that autoimmunity is implicated in the pathogenesis of neuromyotonia. Antibodies to voltage gated potassium channel were detected in the serum of patients who had peripherical nerves hyperexcitability and also Morvan’s disease or limbic encephalitis. These discoveries offered new approaches to treatments. Recently, antibodies previousl...

Axon guidance cues of the ephrin ligand family have been hypothesized to regulate the formation of thalamocortical connections, but in vivo evidence for such a role has not been examined directly. To test whether ephrin-mediated repulsive cues participate in sorting the projections originating from distinct thalamic nuclei, we analyzed the organization of somatosensory and anterior cingulate af...

In this issue Kairavi Bhardwaj et al. reported an interesting case of a 65-year-old woman who presented with memory loss, repetitive episodes of focal seizures without loss of consciousness, with behavioral abnormalities. Imaging suggested a diagnosis of limbic encephalitis which was further confirmed with antibody LGI1 being positive. Limbic encephalitis (LE) is a rarely neurological disorder ...

The septal area is an important anterior component of the limbic system. It is located on the medial surface of the cerebral hemisphere nestled inferior to the rostrum of the corpus callosum and anterior to the third ventricle and lamina terminalis (Fig 1) (1). This small area is contiguous with components of the limbic system curving around the corpus callosum (Fig 2) as well as structures on ...