Coordination of limb segments in graphic motor behavior has been studied primarily in cyclic tasks. In the present study, limb segment recruitment patterns were investigated in a discrete line-drawing task. Subjects ( N = 11) performed pointing movements varying in direction, amplitude, and speed. The contributions of index finger, hand, and arm to the movement were analyzed by evaluating the a...

OBJECTIVE Studies on upper limb recovery following stroke have highlighted the importance of the structural and functional integrity of the corticospinal tract (CST) in determining clinical outcomes. However, such relationships have not been fully explored for the lower limb. We aimed to test whether variation in walking impairment was associated with variation in the structural or functional i...

OBJECTIVES Describe the rationale and protocol for the Upper Limb International Spasticity (ULIS)-III study, which aims to evaluate the impact of integrated spasticity management, involving multiple botulinum toxin A (BoNT-A) injection cycles and concomitant therapies, on patient-centred goal attainment. Outline novel outcome assessment methods for ULIS-III and report initial evaluation data fr...

Background Advanced neuroimaging and computational methods offer opportunities for more accurate prognosis. We hypothesized that near-term regional white matter (WM) microstructure, assessed on diffusion tensor imaging (DTI), using exhaustive feature selection with cross-validation would predict neurodevelopment in preterm children. Methods Near-term MRI and DTI obtained at 36.6 ± 1.8 weeks p...

Developmental processes and their results, morphological characters, are inherited through transmission of genes regulating development. While there is ample evidence that cis-regulatory elements tend to be modular, with sequence segments dedicated to different roles, the situation for proteins is less clear, being particularly complex for transcription factors with multiple functions. Some mot...

This thesis presents a novel appearance prior for model-based image segmentation. This appearance prior, denoted as Multimodal Prior Appearance Model (MPAM), is built upon an EM clustering of intensity pro les with model order selection to automatically select the number of pro le classes. Unlike classical PCAbased approaches, the clustering is considered as regional because intensity pro les a...

Previous classification systems of chronic osteomyelitis have failed to provide objective and pragmatic guidelines for selection of the appropriate treatment strategy. In this study, we assessed the short-term treatment outcome in adult patients with long-bone chronic osteomyelitis prospectively where a modified host classification system was integrated with treatment strategy selection through...

OBJECTIVE To identify valid and reliable outcome measures reflective of "real-life" active and passive function for application following focal rehabilitation interventions in the hemiparetic upper limb after stroke or brain injury. METHODS A systematic review of the literature, incorporating a wide-based search including electronic databases, primary reports, abstracts and conference proceed...