نتایج جستجو برای: like growth factor igf
تعداد نتایج: 2006203 فیلتر نتایج به سال:
Elevated expression of insulin-like growth factor-II (IGF-II) is frequently observed in a variety of human malignancies, including breast, colon, and liver cancer. As IGF-II can deliver a mitogenic signal through both IGF-IR and an alternately spliced form of the insulin receptor (IR-A), neutralizing the biological activity of this growth factor directly is a potential alternative option to IGF...
Insulin-like growth factor II is a growth factor important in fetal development. Several cancer tissues and cell lines have been reported to express IGF-II and rat IGF-II is mitogenic for breast cancer cell lines. Using Northern analysis and ribonuclease protection assays, IGF-II mRNA was detected in normal fibroblasts and in the established breast cancer cell line, T47D. In this cell line, ste...
Insulin-like growth factor-I receptor (IGF-IR) signaling is required for carcinogenicity and proliferation of gastrointestinal (GI) cancers. We have previously shown significant therapeutic activity for recombinant adenoviruses expressing dominant-negative insulin-like growth factor-I receptor (IGF-IR/dn), including suppression of tumor invasion. In this study, we sought to evaluate the mechani...
Background: Morphine is wildly used as a painkiller in clinics, but causes several side effects such as hyperalgesia, depression and more notably amnesia. Here, we assumed that insulin-like Growth Factor-1 (IGF-1) as a peptide with widespread distribution of receptors in brain regions, especially hippocampus, might be capable to alleviate morphine-induced amnesia. Meth...
Background :-Breast cancer is responsible for the death of millions of women worldwide every year. It is widespread in the world and Iraq that become a genuine problem for public health. The etiology of the disease is unknown. Genetic and hormonal factors are involved in the development of breast cancer and progression of the disease. Insulin like growth factor-ӏ (IGF-ӏ) have been implicated as...
Both estrogen and hydrogen sulfide (H 2 S) inhibit the proliferation of vascular smooth muscle cells (SMCs) development atherosclerosis. In absence endogenous H S as occurred in CSE-knockout (KO) mouse, however, stimulates SMCs. The underlying mechanisms for this seemingly controversial effect are unclear. present study, we demonstrated that stimulatory on CSE-KO SMCs was suppressed by inhibito...
OBJECTIVE The effect of insulin-like growth factor-1 (IGF-1) on energy expenditure and protein and glucose metabolism in a group of patients with thermal injury was determined. SUMMARY BACKGROUND DATA Accelerated protein catabolism is a constant feature of the hypermetabolic response to thermal injury. Insulin-like growth factor-1 has been reported to minimize protein catabolism and normalize...
Molloy, et. al., (2003) address specific growth factors encountered in ligament and tendon healing. After reading about the factors found in superficial wounds, above, these should appear familiar, including: Platelet derived growth factor (PDGF)—produced shortly after tendon injury, stimulates production of other growth factors such as IGF-1, and is involved in the tissue remodeling phase of h...
Diseases of aging produce many alterations in the retina, but changes in growth factor signaling in normal aging are less characterized. This study investigated modifications in insulin-like growth factor-1 (IGF-1) receptor (IGF-1R) signaling in the retina of Brown Norway x Fischer 344 F1 hybrid rats at 8, 22, and 32 months. Immunoblotting for proteins involved in IGF-1R signal transduction and...
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