like growth factor

Insulin-like growth factors (IGF) have mitogenic and antiapoptotic functions, and may be involved in tumor growth. The purpose of the study was to investigate the role of IGF components in seminoma compared to normal testis. Normal testicular tissues from autopsy cases and seminoma from surgery cases were obtained for microarray and real-time reverse transcription polymerase chain reaction (RT-...

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Molecular characteristics of fibroblast growth factor-fibroblast growth factor receptor-heparin-like glycosaminoglycan complex

Journal: :Proceedings of the National Academy of Sciences 1999

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Insulin-like growth factor-I prevents apoptosis in neurons after nerve growth factor withdrawal

Journal: :Journal of Neurobiology 1998

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Cellular actions of the insulin-like growth factor binding proteins.

Journal: :Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 1999

Sue M Firth Robert C Baxter

In addition to their roles in IGF transport, the six IGF-binding proteins (IGFBPs) regulate cell activity in various ways. By sequestering IGFs away from the type I IGF receptor, they may inhibit mitogenesis, differentiation, survival, and other IGF-stimulated events. IGFBP proteolysis can reverse this inhibition or generate IGFBP fragments with novel bioactivity. Alternatively, IGFBP interacti...

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