Selective autophagy contributes to the degradation of condensates, such as sequestosome 1-bodies, also called p62/SQSTM1-bodies. We showed that endogenous p62 forms gel-like structures, which serve platforms for autophagosome formation and nuclear factor erythroid 2-related 2 (NRF2) activation. Further, p62-mediated NRF2 activation is not cytotoxic, but combination with impaired bulk selective ...

The dictyate nucleus of the growing mouse oocyte exhibits, besides the nucleolus, 3 ultrastructurally distinct types of smaller formed entities referred to as extranucleolar bodies. The extranucleolar bodies of the first type (fibrillogranular bodies) consist of intermingled masses made up of closely arranged convoluted fibrils, 6-10 nm in width, interspersed with electrondense granules approxi...

monitoring and assessment of water has become environmental concern due to the contamination by man kind. one of the most important crises of the 21st century is the availability of drinking water, a resource basic to our survival and growth. most of the fresh water bodies all over the world are getting polluted thus decreasing the suitability of the fresh water. the area of the study, selected...

The promyelocytic leukemia (PML) protein has been implicated in many cellular pathways, but it is unclear whether the accumulation of PML and other proteins into PML nuclear bodies is a regulated or random process. In this paper we have used a variety of physiological stresses, including heat stress, Cd+2 exposure and adenovirus E1A expression, as tools to study the principles underlying the as...