The treatment of [1,1-(PR3 )2 -3-(Py)-closo-1,2-RhSB9 H8 ] (PR3 =PMe3 (2) or PPh3 and PMe3 (3); Py=pyridine) with triflic acid (TfOH) affords [1,3-μ-(H)-1,1-(PR3 )2 -3-(Py)-1,2-RhSB9 H8 ](+) (PR3 =PMe3 (4) or PMe3 and PPh3 (5)). These products result from the protonation of the 11-vertex closo-cages along the Rh(1)B(3) edge. These unusual cationic rhodathiaboranes are stable in solution and in...

The cis – trans -isomerism of the propiolic acid monomer (HCC–COOH) is examined with linear Raman jet spectroscopy, yielding first environment-free vibrational band centres a higher-energy -rotamer beyond formic (HCOOH) in addition to all fundamentals and large number hot combination/overtone bands -conformer.

and his colleagues present a detailed and careful analysis of the arrangement of the heart and thoraco-abdominal organs in a large series of over one thousand autopsied patients.1 Their findings bear directly upon the controversy in which I was recently involved at the 3rd World Congress of Pediatric Cardiology and Cardiac Surgery. The controversy sessions took place on the last day of the Symp...

General anesthetics are a class of drugs whose mode of action is poorly understood. Here, two photoactivable general anesthetics, n-octan-1-ol geometric isomers bearing a diazirine group on either the third or seventh carbon (3- and 7-azioctanol, respectively), were used to locate and delineate an anesthetic site on adenylate kinase. Each photoincorporated at a mole ratio of 1:1 as determined b...

Nuclear isomers are the metastable excited states of nuclei. The can be categorized into a few classes including spin, seniority, K, shape and fission depending upon hindrance mechanisms. In this paper, we aim to present an overview seniority isomers, which is category related quantum number. discussion mainly based on concepts generalized seniority. Various aspects their whereabouts have been ...

The specificity of the binding site of p42IP4, a high-affinity 42 kDa Ins (1,3,4,5)P4 receptor protein identified by photoaffinity labelling (Reiser et al., Biochem. J. 280, 533, 1991) was analyzed by determining the affinities for all possible inositoltris-, -tetrakis-, and -pentakisphosphate regioisomers. We tested the purified receptor protein displaying a Kd of 2.2 nM for Ins (1,3,4,5)P4 wh...

The LA repeats that comprise the ligand-binding domain of the LDL receptor are among the most common autonomously structured extracellular modules found in the nonredundant protein sequence database. Here, we investigate the information content of the amino acid sequence of a typical LA module by constructing sequences with alanine residues at nonconserved positions in the module. Starting with...

Easily prepared and highly modular organic amide proligands have been used to synthesize a series of new bis(amidate)-bis(amido) Ti and Zr complexes via protonolysis. These complexes have been structurally characterized by NMR spectroscopy and X-ray crystallography. The solid-state molecular structures of these complexes indicate that the amidate ligands bind to the metal centers in an exclusiv...

Free fatty acids (FFA) are essential components of the cell, where they play a key role in lipid and carbohydrate metabolism, and most particularly in cell membranes, where they are central actors in shaping the physicochemical properties of the lipid bilayer and the cellular adaptation to the environment. FFA are continuously being produced and degraded, and a feedback regulatory function has ...

The electron spin resonance spectra of 1-myristoyl-2-[n-(4,4-dimethyloxazolidine-N-oxyl)myristoyl]-sn- glycero-3-phosphocholine spin-label positional isomers (n = 6, 10, and 13) have been studied in oriented, fully hydrated bilayers of dimyristoylphosphatidylcholine, as a function of temperature and magnetic field orientation. The spectra have been simulated using a line-shape model which incor...