We report on a patient suffering from seizures caused by cerebral metastases of adenocarcinoma the lung. Initially, was treated effectively with oral levetiracetam. As disease progressed, intake no longer possible. Since levetiracetam had controlled patient's well, medication delivery mode switched first to intravenous application, followed return administration. After further deterioration, su...

I read with great interest the study by van Tuijl et al. aimed to investigate the anti-epileptogenic effect of levetiracetam in stroke patients in order to prevent poststroke seizures and epilepsy. However, due to several problems encountered during execution of this trial, the authors concluded that this trial seems not feasible. On the basis of the similarity of the cascade of synaptic and in...

Studies of individuals with amnestic mild cognitive impairment (aMCI) have detected hyperactivity in the hippocampus during task-related functional magnetic resonance imaging (fMRI). Such elevated activation has been localized to the hippocampal dentate gyrus/CA3 (DG/CA3) during performance of a task designed to detect the computational contributions of those hippocampal circuits to episodic me...

BACKGROUND & OBJECTIVES Certain antiepileptic drugs (AEDs) such as valproic acid (VPA) are known to affect body weight, and lipid profile. However, evidences regarding effects of AEDs on the body composition are deficient. This cross-sectional study compared the body composition and lipid profile among patients with epilepsy on newer and conventional AEDs. METHODS The patients with epilepsy (...

The aim of this study was to test the potential neurotoxicity of three antiepileptic drugs (AEDs), carbamazepine (5H-dibenzepine-5-carboxamide), topiramate [2,3:4,5-bis-O-(1-methylethylidene)-beta-d-fructopyranose sulfamate], and levetiracetam [2-(2-oxopyrrolidin-1-yl)butanamide], in the developing rat brain, when given alone or in combinations. The extent of cell death induced by AEDs was meas...

A 22-year-old female with a history of developmental delay and seizures successfully treated with carbamazepine and levetiracetam developed fulminant hepatic failure and subsequently died. She had been admitted to the hospital following secondary generalized seizures of 35 min duration. A circulatory shock as well as intoxication was taken into consideration during the clinical course. Autopsy ...

We present the case of a 45-year old woman diagnosed of partial complex epilepsy from childhood that was stabilized with carbamazepine 400 mg/day over all the years. Due to the decrease in libido secondary to this drug, she began to have problems in her personal life so that her attending neurologist decided to switch her to levetiracetam 1500 mg/day. Two months after the change in anti-epilept...