Myosin couples ATP hydrolysis to the translocation of actin filaments to power many forms of cellular motility. A striking feature of the structure of the muscle myosin head domain is a 9-nm long "lever arm" that has been postulated to produce a 5-10-nm power stroke. This motion must be coupled to conformational changes around the actin and nucleotide binding sites. The linkage of these sites t...

he longest journey may begin with a single step, but, in the case of myosin motor proteins moving along actin filaments, the start of the walking stride has been nearly impossible to observe. Now Burgess et al., reporting on page 983, reveal the prepower stroke conformation of myosin on actin, clearing a major hurdle to understanding myosin activity. Previous work on myosin has focused primaril...

he longest journey may begin with a single step, but, in the case of myosin motor proteins moving along actin filaments, the start of the walking stride has been nearly impossible to observe. Now Burgess et al., reporting on page 983, reveal the prepower stroke conformation of myosin on actin, clearing a major hurdle to understanding myosin activity. Previous work on myosin has focused primaril...

In this paper, we demonstrate a frequency modulation technique to accurately measure the probe Stark shift of optical clocks. The effective coupling strength laser clock transition is precisely controlled by technique, which different from traditional method controlling via changing light power. an 87Sr lattice clock, shifts are measured as function square bare state strength. coefficient exper...

Proper orientation of the shoulder and elbow is necessary for accurate and precise positioning of the hand. The authors' goal was to compare these joints with an active joint position sense task, while also taking into account the effects of joint flexion angle and arm dominance. Fifteen healthy subjects were asked to replicate presented joint angles with a single degree of freedom active posit...