Leukotrienes are lipid messenger molecules that are secreted by leukocytes to orchestrate a rapid and prolonged immune response. The enzyme 5-lipoxygenase catalyzes the rate-limiting first two steps in the synthesis of leukotrienes from arachidonic acid. Although it has long been known that 5-lipoxygenase moves from the cytoplasm to a membrane following activation, it has only recently been rec...

Neutrophils serve as a vanguard of the acute innate immune response to invading pathogens. Neutrophils are also abundant at sites of autoimmune inflammation, such as the rheumatoid joint, although their pathophysiologic role is incompletely defined and relevant effector functions remain obscure. Using genetic and pharmacologic approaches in the K/BxN serum transfer model of arthritis, we find t...

Prostaglandins have been known for a long time to have a vaso-active action. The recent discovery that prostacycline or thromboxane A2 have a greater vascular action than the prostaglandins suggests that these substances may have a physiological or pathological role, for example in endotoxin shock, anaphylaxis, coronary thrombosis, chronic hypertension, etc. The discovery of the leukotrienes an...

Leukotrienes are potent proinflammatory mediators derived from of arachidonic acid through the 5- lipoxygenase pathway. Experimental data suggest a role for cysteinyl leukotrienes in the pathogenesis of atopic dermatitis and there is a rationale for the use of pharmacological agents to antagonize their effects in the treatment of atopic dermatitis. We report 2 cases of severe atopic dermatitis ...

BACKGROUND The hyperimmunoglobulinaemia D and periodic fever syndrome is a hereditary periodic fever, caused by deficiency of the enzyme mevalonate kinase. It is unclear how this defect leads to recurrent fever episodes. AIM To assess the involvement of cysteinyl leukotrienes in the pathogenesis of fever attacks as reflected by urinary leukotriene E(4) (LTE(4)) excretion. METHODS Urinary LT...

5-Lipoxygenase-derived products have been implicated in both the inhibition and promotion of chronic infection. Here, we sought to investigate the roles of endogenous 5-lipoxygenase products and exogenous leukotrienes during Histoplasma capsulatum infection in vivo and in vitro. 5-LO deficiency led to increased lung CFU, decreased nitric oxide production and a deficient primary immune response ...

EARLY ACUTE LUNG INJURY (ALI) IS characterizedbyneutrophiliclung inflammation,permeability,and intravascular and alveolar fibrin deposition. The proinflammatory and prothrombotic fatty acid eicosanoid derivatives of cyclooxygenase (eg, thromboxaneA2)and5-lipoxygenase(eg,leukotrieneB4)enzymesaremediatorsof these processes. The type and inflammatory activity of eicosanoids liberated during inflam...

Leukotrienes have been implicated as important mediator in a bronchial asthma. The purpose of this study is to evaluate the degree of participation of leukotrienes on onset of symptoms of nasal allergy. We measured leukotriene C4 and D4 (LTC4 and LTD4) in nasal secretion by radioimmunoassay combined with high performance liquid chromatography. This method is superior to the one previously repor...

Primary Dysmenorrhea is literally termed as Painful menstruation. Most of the women do suffer with painful menses which intervenes in their day to activities. cause pain due excessive vasopressin, leukotrienes, prostaglandin, myometrial ischemia, uterine malformation. may present abdomen before or during menses, associated nausea, tachycardia, irritability, fatigue, and headache. In this study ...