نتایج جستجو برای: leukocyte telomere length
تعداد نتایج: 346584 فیلتر نتایج به سال:
OBJECTIVE Shorter telomere length is associated with the occurrence of cardiovascular events, but the question of causality is complicated by the intertwined effects of inheritance, aging, and lifestyle factors on both telomere length and cardiovascular disease (CVD). Some studies indicated that healthy offspring of coronary artery disease patients exhibited shorter telomeres than subjects with...
.................................................................................................................................... 2 Populärvetenskaplig sammanfattning .............................................................................. 4 List of commonly used abbreviations ............................................................................... 6 Original Papers ...............
Telomeres are repetitive sequences of variable length at the ends of chromosomes involved in maintaining their integrity. Telomere dysfunction is associated with increased risk of cancer and other age-related diseases. Telomere length is an important determinant of telomere function and has a strong genetic basis. We previously carried out a genome-wide linkage analysis of mean leukocyte telome...
Background & objective: Mesenchymal stem cells (MSCs) are presently isolated from various human tissues such as bone marrow. These cells have relatively high replication potential and can differentiate into various cell lineages with mesodermal and non-mesodermal origin and therefore, show promising in treatment of diseases. Their striking features like availability of source, ease of isolation...
Some have suggested that chronic obstructive pulmonary disease (COPD) is a disease of accelerated aging. Aging is characterized by shortening of telomeres. The relationship of telomere length to important clinical outcomes such as mortality, disease progression and cancer in COPD is unknown. Using quantitative polymerase chain reaction (qPCR), we measured telomere length of peripheral leukocyte...
CONTEXT Telomeres are essential to preserve the integrity of the genome. Critically short telomeres lead to replicative cell senescence and chromosomal instability and may thereby increase cancer risk. OBJECTIVE To determine the association between baseline telomere length and incident cancer and cancer mortality. DESIGN, SETTING, AND PARTICIPANTS Leukocyte telomere length was measured by q...
Telomeres consist of nucleotide repeats and a protein complex at chromosome ends that are essential to maintaining chromosomal integrity. Several studies have suggested that subjects with shorter telomeres are at increased risk of bladder and lung cancer. In comparison to normal tissues, telomeres are shorter in high-grade intraepithelial neoplasia and prostate cancer. We examined prostate canc...
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