Vowels, M. R., and Willoughby, M. L. N. (1973). Archives of Disease in Childhood, 48, 436. Cyclic chemotherapy in acute lymphoblastic leukaemia: 5-year survivals. Of 31 children with acute lymphoblastic leukaemia treated with a cyclical scheme of chemotherapy, 19% survived for over 5 years, 16% remained in continuing haematological remission for 5 years, and 13% remained leukaemia free for 5 ye...

We report on a case of T-cell chronic lymphocytic leukaemia involving the lung, with clinical, radiological and histological evidence of relapsing bronchiolitis obliterans-organizing pneumonia in a 70-yr-old female. Pulmonary disease was the major clinical manifestation of this chronic lymphocytic leukaemia. The first two episodes of the patient's pulmonary disorder resolved without treatment, ...

• The aetiology of childhood leukaemia has been associated with exposure to infections and there is some emerging evidence for similar links to CNS tumours. • A comparison of the descriptive epidemiology of these two conditions may offer some insights into other similarities. • International incidence rates of childhood leukaemia and CNS tumours show a significant, positive association. • There...

Chronic lymphocytic leukaemia has developed in three siblings who are all carriers of the abnormal Ch(1) chromosome. (3)H-thymidine autoradiography showed Ch(1) to be a G(2) autosome, from which the short arm is absent, and not G(1), which is trisomic in Down's syndrome and which is believed to form the abnormal Ph(1) chromosome. Ch(1) is not of general significance in the aetiology of chronic ...

We report a case of non-sideroblastic refractory anaemia which evolved to a double lymphomyeloproliferative disorder. At presentation, bone marrow appearances and peripheral blood pancytopenia without myelomonocytosis were consistent with a diagnosis of non-sideroblastic refractory anaemia. Subsequently, the patient developed pronounced myelomonocytosis and lymphocytosis with prolymphocytes. Li...

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LEUKAEMIC infiltration of the lacrimal sac is rare (Duke-Elder, 1952) and dacryocystitis due to leukaemic involvement of the sac has seldom been reported (Stokes, 1938; Busina, 1950). The number of cases recorded is increased when the reports of Sulzer and Duclos (1906), Pascheff (1927), and Weve (1928) are considered, but these authors described lymphomata of the sac without the typical blood ...

OBJECTIVES To investigate the risk of leukaemia in workers in the petroleum distribution industry who were exposed to low levels of benzene. METHODS From the cohort of distribution workers, 91 cases were identified as having leukaemia on either a death certificate or on cancer registration. These cases were compared with controls (four per case) randomly selected from the cohort, who were fro...

Hypereosinophilia as first clinical presentation has rarely been reported in paediatric acute lymphoblastic leukaemia. It is commonly associated with specific cytogenetic abnormalities. Although eosinophilia is considered a reactive, non-neoplastic epiphenomenon, it adversely affects patient outcomes, both in children and adults. We describe herewith two paediatric patients who had marked eosin...

Acute leukaemia of ambiguous lineage (ALAL) is a rare form of leukaemia in which morphologic, cytochemical and immuno-phenotypic features of the proliferating blasts lack sufficient evidence to classify them as myeloid or lymphoid in origin or have characteristics of both myeloid and lymphoid cells. We report a 22-year-old man presenting with clinical features of an acute lymphoblastic leukaemi...