نتایج جستجو برای: lethal dose
تعداد نتایج: 346673 فیلتر نتایج به سال:
background and objectives : due to the extensive use of antibiotics, the spread of drug-resistant bacteria is one of the most worrisome threats to public health. one strategy that can be used to overcome potential shortcomings might be the inactivation of these organisms by photodynamic therapy. in this study, we have investigated whether drug-resistant wound-associated organisms (staphylococcu...
toxic effects of malathion and endosulfan to fertile chicken eggs were determined. in-jection of 1.25, 2.5, 5.0 and 10.0 mg/egg of malathion into yolk sac of fertile eggs prior to incubation caused mortality of 10.0, 30.0, 83.33 and 93.33% respectively. similar trend was observed with injection of endosulfan doses. malathion and endosulfan at 1.25 mg/egg caused no pronounced ld50 increase in mo...
A wide range of dose-rates have been used in radiation biology and radiation therapy, extending from a few cGy per day to hundreds of Gy in a fraction of a second. The dose-rate range of importance in radiotherapy extends from about 0.1 Gy/hr to several Gy/min. In this range, the fraction of cells killed by a given dose decreases as the dose-rate is reduced, principally because of the repair of...
The mouse model has been used previously for the study of protection against challenge with strains of group B Streptococcus types Ia, Ib, and Ic, but investigators have not yet been successful in causing lethal disease when type III strains are inoculated. In this study, six clinical isolates belonging to serotype III were lethal in seven-week-old outbred albino mice; the 50% lethal dose (LD50...
Renealmia alpinia (Rottb.) MAAS, obtained by micropropagation (in vitro) and wild forms have previously been shown to inhibit some toxic activities of Bothrops asper snake venom if preincubated before injection. In this study, assays were performed in a murine model in which extracts were administered for three days before venom injection. R. alpinia extracts inhibited lethal activity of B. asp...
Biologically motivated mathematical models, which describe the dynamics of the thrombocytopoietic, granulocytopoietic and erythropoietic systems in irradiated humans, are developed and thoroughly investigated [1–3]. These models are implemented as the systems of non-linear ordinary differential equations, whose variables and constant parameters have clear biological meaning. The modeling studie...
Male beagles were bilaterally exposed to mixed gamma-neutron radiation from the AFRRI-TRIGA reactor. The dose rate was 20 rads/minute for all irradiations and midline tissue doses were 215 rads, 225 rads and 240 rads. At each dose approximately one-half of the animals received a single irradiation while the others were given one-fourth the dose each day for 4 consecutive days. The objective of ...
BACKGROUND The pathogenesis of sepsis is mediated in part by bacterial endotoxin, which stimulates macrophages/monocytes to sequentially release early (e.g., TNF, IL-1, and IFN-gamma) and late (e.g., HMGB1) pro-inflammatory cytokines. Our recent discovery of HMGB1 as a late mediator of lethal sepsis has prompted investigation for development of new experimental therapeutics. We previously repor...
The extensive analysis of the impact of segmental aneuploidy by Lindsley et al. (1972) showed that there are relatively few haplo-lethal loci in the genome and that, with one exception, all loci are triplo-viable. The exceptional locus, which lies in salivary gland chromosome region 83D-E, is associated with lethality when present in either one or three doses in an otherwise diploid individual ...
Epsilon toxin (ETX) is produced by toxinotypes B and D of Clostridium perfringens. It can induce lethal enterotoxemia in domestic animals, mainly in sheep, goats and cattle, causing serious economic losses to global animal husbandry. In this study, a novel and stable epsilon toxin mutant rETX(Y196E)-C, obtained by substituting the 196th tyrosine (Y196) with glutamic acid (E) and introducing of ...
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