This study examined the relationships among physical activity, glucocorticoid use, body composition, and bone health in ambulatory women with multiple sclerosis (MS). Twenty-nine white women (mean +/- standard deviation: age 45.1 +/- 9.0 yr, Expanded Disability Status Scale 2.9 +/- 1.2) diagnosed with MS were assessed for whole body (WB), proximal femur (PF) and lumbar spine (LS) bone status (b...

BACKGROUND Whether testosterone treatment has benefits on body composition over and above caloric restriction in men is unknown. We hypothesised that testosterone treatment augments diet-induced loss of fat mass and prevents loss of muscle mass. METHODS We conducted a randomised double-blind, parallel, placebo controlled trial at a tertiary referral centre. A total of 100 obese men (body mass...

Potassium has long been known to be almost completely confined to the intracellular compartment, and the neutral fat present in muscle has been shown to have a low chloride content (1). It seemed probable, therefore, that the error associated with predictions of total exchangeable electrolyte from total body weight would diminish if the variable of depot fat was eliminated by the use of lean bo...

BACKGROUND Vitamin D insufficiency (serum 25-OH vitamin D > 10 ng/ml and < 30 ng/ml) is prevalent in the obese (body mass index (BMI) > 30 kg/m2), yet relationships between the two are poorly understood. Objectives of this study include identification of the impact of obesity on reducing serum 25-OH vitamin D concentration, particularly in response to altered vitamin D3 supplementation, and to ...

Background It has frequently been demonstrated that resistance training has a negative effect on muscle glycogen content. Additionally, the rate of resynthesis seems to be dependent upon the degree of depletion. However, the impact of glycogen resynthesis on lean mass in a resistance trained population consuming a very low carbohydrate diet has yet to be examined. This has important implication...

BACKGROUND In adults, dosages of some anaesthetic agents are based on lean body mass (LBM) rather than body weight. Our aim was to derive an equation for estimating LBM in children. METHODS Patients comprised three groups: prospective kidney transplant donors from two separate centres (centres 1 and 3) and children referred to a further centre (centre 2) for the routine clinical measurement o...

BACKGROUND Sarcopenic obese (SO) individuals are a unique subset of subjects that combines obesity and sarcopenia. Traditional weight loss programmes including aerobic exercises may worsen their condition by further reducing their lean mass. The objective of this observational and retrospective study was to verify the effect of a mixed weight loss programme combining caloric restriction and exe...

BACKGROUND Human ageing is a process characterized by loss of muscle mass, strength, and bone mass. We aimed to examine the efficacy of low-dose creatine supplementation associated with resistance training on lean mass, strength, and bone mass in the elderly. METHODS This was a 12-week, parallel-group, double-blind, randomized, placebo-controlled trial. The individuals were randomly allocated...