In January 2012, Boström and colleagues identified a new muscle tissue secreted peptide, which they named irisin, to highlight its role as a messenger that comes from skeletal muscle to other parts of the body. Irisin is a cleaved and secreted fragment of FNDC5 (also known as FRCP2 and PeP), a member of fibronectin type III repeat containing gene family. Major interest in this protein arose bec...

Most children who die in the UK have an underlying chronic illness, and the majority of these deaths take place in a paediatric intensive care unit (PICU). The overall community burden of paediatric chronic illness is increasing as the population expands and as children with chronic conditions live longer. Improvements in public health measures, and in the recognition and management of paediatr...

About twenty years ago the measure of smoothness ω φ (f, t) was introduced and related to the rate of polynomial approximation. In this article we survey developments about this and related concepts since that time. MSC: 41A10, 41A17, 41A25, 41A27, 41A30, 41A36, 41A40, 41A50, 41A63, 26A15, 26B35, 26B05, 42C05, 26A51, 26A33, 46E35 keywords: Moduli of smoothness, K-functionals, realization functi...

The first RTA conference took place in Dijon, in 1985. This year, 2005, it takes place in Nara. Nara and Dijon share a glorious past but can be considered as being “Sleeping Beauties”, after the title of a book by the Nobel price novelist yasunari Kawabata. Is RTA sleeping on its glorious past ? Back in the late 80s, many of us feared that this would soon be the case, that research in rewrite s...

The place of Neandertals in modern human emergence has been a subject of debate since the first recognized Neandertal skeleton was discovered in 1856. This paper presents an overview of morphological, archaeological, and genetic evidence commonly used in discussions of Neandertals and their evolutionary significance. A brief historical sketch of the argument provides insight into the changing v...

Elliptical galaxies are modelled as homeoidally striated Jacobi ellipsoids (Caimmi & Marmo 2005) where the peculiar velocity distribution is anisotropic, or equivalently as their adjoints configurations i.e. classical Jacobi ellipsoids of equal mass and axes, in real or imaginary rotation (Caimmi 2006). Reasons for the coincidence of bifurcation points from axisymmetric to triaxial configuratio...

Although conceived at the end of the 19th century as a synthetic analgesic agent with improved gastric tolerability vs. naturally occurring salicylates, acetylsalicylic acid (marketed as aspirin in 1899) turned out to be an ideal antiplatelet agent about 90 years later, following the understanding of its mechanism of action, the development of a mechanism-based biomarker for dose-finding studie...

housing for LGBT elders. Generations, 29(4), 65–70. de Vries, B. (2007). LGBT couples in later life: A study in diversity. Generations, 31(3), 18–23. de Vries, B., & Blando, J. A. (2004). The study of gay and lesbian lives: Lessons for social gerontology. In G. Herdt & B. de Vries (Eds.), Gay and lesbian aging: research and future directions (pp. 3–28). New York: Springer. de Vries, B., & Hocte...