Langerhans cell histiocytosis (LCH), previously known as histiocytosis X, is an uncommon hematological disorder affecting infants and young children. It is the condition characterized by uncontrolled stimulation and proliferation of normal antigen presenting cells, Langerhans cells. Because of its relatively low incidence, limited data are available regarding the epidemiology of LCH, with estim...

Rosai–Dorfman disease (RDD) is a rare non-Langerhans cell histiocytosis that was first described as sinus with massive lymphadenopathy by Rosai and Dorfman in 1969. While classical/nodal RDD typical, extranodal involvement seen up to 43% of all cases, 23% showing only lesions. Here, we present case disseminated RDD, where the initial symptoms were cutaneous manifestations.

Cigarette smoking is a major risk factor for pulmonary Langerhans cell histiocytosis (pLCH) and lung cancer. Resolution of pLCH may occur spontaneously, after smoking cessation or other interventions. However, despite clinicoradiological resolution, residual pulmonary Langerhans cells may be present and may lead to recurrent disease. We report the first case of pLCH with a complete histological...

vertebra plana is a radiological diagnosis that indicates complete compression of the vertebral body.(1,2) this condition was reported in langerhans cell histiocytosis including eosino-philic granuloma,(3, 12) ewing's sarcoma,(2,13,14) tuberculosis,(15,16) vertebral osteomyelitis,(17) aseptic necrosis,(18) aneurysmal bone cyst,(19) osteosarcoma,(20) neuroblastoma,(21) acute leu-kemia,(22) rhabd...

Langerhans cell histiocytosis (LCH) is a rare disease in which Langerhans cells, which are bone marrow-derived antigen-presenting cells, proliferate in single or multiple organs. We successfully treated a patient with unifocal LCH of the mandible with malocclusion due to a severe pathological fracture, using reconstruction with a vascularised free bone.

We report a patient with vulvar lichen sclerosus, Langerhans cell histiocytosis (LCH), and later vulvar cancer. In LCH, high amounts of non functional Langerhans cells are present in the affected tissue, making it possible that LCH may have contributed to vulvar cancer development in this patient.

Pulmonary Langerhans cell histiocytosis is a rare interstitial lung disease. It's morbidity is estimated at 4-5 person per million. The multiformity--from benignity to severe--brings difficulties during the process of diagnosis. The authors describe a case of 48-year-old woman with a benign pulmonary lung histiocytosis. It is underlined the diagnostic quality of high resolution tomography and b...

Langerhans cell histiocytosis (LCH) is a rare neoplasm defined as the proliferation of bone marrow langerhans cells, which is a kind of dendritic cells. The major pathological features of LCH are expression of CD1a and S100 as well as Birbeck granules. Its presentation can differ from a mild bone lesion to a multi-systemic evolved malignant neoplasm; however, the latter outcome is almost rare. ...