The present work focuses the study of wall shear stress-based descriptors: time averaged wall shear stress (TAWSS), oscillating shear index (OSI) and relative residence time (RRT), of sketch geometries of the left coronary artery (LCA): one healthy case, one disease case with 30% obstruction in the left anterior descending artery (LAD) and other disease case with 50% obstruction in the LAD. Mor...

Fig. 1. LAO angiographic view failing to visualize the accurate course of distal LAD (black arrowheads) (A). CT curved multiplanar reconstruction demonstrating clearly the distal segment of LAD (B). Cx: circumflex artery; Dg: diagonal branch; LAD: left anterior descending artery. Fig. 2. CT sagittal maximum intensity projection performed 12 months after surgical revascularization confirmed good...

Chronic bullous disease of childhood (CBDC) is an autoimmune blistering disease that is characterized by Immunoglobulin A (IgA) deposits at the basement membrane zone. IgA autoantibodies (aAbs) from the serum of patients with CBDC react with antigens of 97 kDa (LABD97) and 120 kDa (LAD-1), and both of which are fragments of the extracellular domain of bullous pemphigoid 180 (BP180, type XVII co...

We present the case of a 58-year-old Jehovah’s Witness admitted to our Institution with unstable angina for the previous two weeks. Past medical history included hypertension, hyperlipidemia and previous testicular cancer treated with resection and chemotherapy about 15 years earlier. At admission, a trans-esophageal echocardiogram (TEE) showed preserved ejection fraction (EF) with no regional ...

Rho GTPases are members of the Ras superfamily of GTPases that regulate a wide variety of cellular functions. While Rho GTPase pathways have been implicated in various pathological conditions in humans, to date coding mutations in only the hematopoietic specific GTPase, RAC2, have been found to cause a human disease, a severe phagocytic immunodeficiency characterized by life-threatening infecti...

We present a case report of a 40-year-old male who underwent elective cardiac catheterization secondary to complaints of intermittent chest pain and inducible ischemia in the anterior wall. Diagnostic catheterization revealed severe coronary artery disease including an occluded mid left anterior descending (LAD) artery. There was a rarely described descending septal artery (Bonapace's branch) o...

BACKGROUND In pigs and humans, the left anterior descending coronary artery (LAD) supplies the left ventricular anterior wall (LVAW), anterior septum, and paraseptal band of the right ventricular anterior wall (RVAW). The purposes of our study were 1) to study the LAD flow distribution in these walls during preexercise, exercise, and exercise with LAD stenosis and 2) to analyze regional wall mo...

BACKGROUND Plasma von Willebrand factor (vWF), a key player in hemostasis and thrombosis, is released from endothelial cells during inflammation. Hypertension, a progressing in chronic inflammation and cardiovascular syndrome with various causes, results in functional and structural changes of heart and arterial vessels. However little information is available on LA changes during hypertension....