The plasma enzymes, lactic dehydrogenase, glutamic oxalacetic transaminase, and malic dehydrogenase, increased pro gressively in tumor-bearing rats. The amount of increase varied markedly with the type of tumor and the site of implantation. A lactic dehydrogenase agent could not be demonstrated in any of these animals. Isozyme patterns indicated the tumor was a significant contributor to the in...
