BACKGROUND A large number of studies have investigated the prognostic value of pretreated lactate dehydrogenase (LDH) level in nasopharyngeal carcinoma (NPC) patients while the role of it was inconsistent and inconclusive. Hence, the aim of the current study was to conduct a meta-analysis of all published studies to quantify the prognostic impact of pretreated serum LDH in NPC for Chinese popul...

METHODS. Cellular reductive capacity was evaluated using WST-1 tetrazolium salt. Mitochondrial transmembrane potential was determined by JC-1 fluorescence. Cellular ATP levels were measured with a luciferase assay. Caspase-3/7 activation was detected with a DEVDase activity assay. Cell death and lysis was evaluated by measuring release of lactate dehydrogenase (LDH). Glycolysis was assessed by ...

Lactate dehydrogenase (LDH) isozyme study in the liver, kidney and testes of Mus terricolor, an indigenous species of India, revealed the presence of a slow migrating variant of LDH isozyme, LDH-C4 along with other five usual LDH isozymes present in other tissues. The synthesis of LDH-C4 is controlled by a separate locus Ldh c. The results have shown differential expression of LDH-C4 and LDH-A4...

Background: Both creatine kinase (CK) and/or lactate dehydrogenase (LDH) mutually are elevatedsignificantly in many tumors. This study hypothesizes that LDH was evaluated as a prognostic factor forsurvival time patients with terminal cancer (PTC). Additionally, CK considered valuable assessingprognosis of advanced patients. aimed to estimate the change CK/LDH levelsin different types comparing ...

Differential scanning microcalorimetry was used to assess the conformational stability of muscle lactate dehydrogenase (M4-LDH) from skeletal muscle of Misgurnus fossilis (loach) fishes adapted to low (the “cold” enzyme) and high (the “warm” enzyme) environmental temperatures. It was found that the denaturation temperature Td was the same for both forms of lactate dehydrogenase, whereas the den...

Concentrations of total lactate dehydrogenase (LDH; EC 1.1.1.27) and LDH isoenzyme patterns were studied in serum of 19 patients with multiple myeloma and in 19 healthy controls. Patients were divided into three groups (pretreatment, nonresponders, and responders to treatment), based on their clinical status at the time of blood sampling for LDH. The LDH values were found to be significantly hi...

Hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome are two diseases caused by hantaviruses. Capillary leakage is a hallmark of hantavirus infection. Pathogenic hantaviruses are not cytotoxic, but elevated levels of serum lactate dehydrogenase (LDH), indicative of cellular damage, are observed in patients. We report increased levels of serum perforin, granzyme B, and the epi...

Lactate (LDH) and malate dehydrogenase (MDH) of white skeletal muscle of fishes acclimated to 20, 25 and 30 degrees C and thereafter submitted to hypoxia were studied in different substrate concentrations. Significant differences for LDH and MDH of white muscle enzyme activities are described here for the first time in Rhinelepis strigosa of fishes acclimated to 20 degrees C and submitted to hy...

The enzyme activities of Lactate dehydrogenase (LDH). prostate fluid LDH isoenzymes phosphohexose isomerase (PHI), Aldolase (ALD) and Hexokinase (HK) were determined in the sera of 77 samples of males. There were 12 cases of carcinoma prostate with metastases, 15 without metastases, 25 with benign prostatic hypertrophy and 25 nontumor. The enzyme activities of nontumor and benign group were sta...

Lactate dehydrogenase (LDH: 3.1.1.27) is a tetrameric enzyme participates in carbohydrate metabolism by catalyzing the oxidation of lactate and reduction of pyruvate. The random tetramerization of LDH-A and -B subunits leads to the formation of five tetramers: LDHB4, LDH-A1B3, LDH-A2B2, LDH-A3B1 and LDH-A4. Due to the biochemical and evolutionary significance of LDH isoenzyme characters or LDH ...