Anderson and Marks (1962) showed that the reabsorption of pyruvate in the kidney tubules of normal subjects is nearly complete. In diabetics, while the plasma concentration of pyruvate may be twice that of normal subjects, the urinary excretion of pyruvate is usually three or four times greater (Takanami et al., 1960 ; Anderson and Mazza, 1963 ; Anderson et al., 1964). Thus the reabsorptive cap...

We evaluated the hypothesis that nutritive needs of injured brains are supported by large and coordinated increases in lactate shuttling throughout the body. To that end, we used dual isotope tracer ([6,6-(2)H2]glucose, i.e., D2-glucose, and [3-(13)C]lactate) techniques involving central venous tracer infusion along with cerebral (arterial [art] and jugular bulb [JB]) blood sampling. Patients w...

BACKGROUND Drinks with higher dissolved oxygen concentrations have in recent times gained popularity as a potential ergogenic aid, despite a lack of evidence regarding their efficacy. The aim of this study was to assess effects of ingestion of an oxygen supplement (OS) on exercise performance and post-exercise recovery in a group of trained runners. METHODS Trained male runners (n = 25, mean ...

The drug of abuse γ-hydroxybutyrate (GHB) displays nonlinear renal clearance, which has been attributed to saturable renal reabsorption by monocarboxylate transporters (MCTs) present in the kidney. MCT1 is also present in red blood cells (RBCs); however, the significance of this transporter on the blood/plasma partitioning of GHB is unknown. The purpose of this research was to characterize the ...

It was recently suggested that the increases in plasma enzyme activity following infection of mice with Riley virus (1) might be due to inhibition of the clearance of enzymes from the blood plasma (2). Preliminary studies confirmed that the plasma clearance of intravenously injected lactate dehydrogenase (LDH) was greatly impaired in Riley virus-infected mice, and also showed that blood clearan...

During septic shock, muscle produces lactate by way of an exaggerated NaKYadenosine triphosphatase (ATPase)Ystimulated aerobic glycolysis associated with epinephrine stimulation possibly through "2 adrenoreceptor involvement. It therefore seems logical that a proportion of hyperlactatemia in low cardiac output states would be also related to this mechanism. Thus, in low-flow and normal-to-highY...

BACKGROUND AND AIMS To validate the lactate clearance (LC) at 6 h for mortality prediction in Pediatric Intensive Care Unit (PICU)-admitted patients and its comparison with a pediatric index of mortality 2 (PIM 2) score. DESIGN A prospective, observational study in a tertiary care center. MATERIALS AND METHODS Children <13 years of age, admitted to PICU were included in the study. Lactate l...

The study investigated the effect of training on lactate and H+ release from human skeletal muscle during one-legged knee-extensor exercise. Six subjects were tested after 7-8 wk of training (fifteen 1-min bouts at approximately 150% of thigh maximal O2 uptake per day). Blood samples, blood flow, and muscle biopsies were obtained during and after a 30-W exercise bout and an incremental test to ...

This study assessed the effectiveness of water immersion to the shoulders in enhancing blood lactate removal during active and passive recovery after short-duration high-intensity exercise. Seventeen cyclists underwent active water- and land-based recoveries and passive water and land-based recoveries. The recovery conditions lasted 31 minutes each and started after the identification of each c...