نتایج جستجو برای: lactase

تعداد نتایج: 1109  

Journal: :The Biochemical journal 1994
S W Lacey H Y Naim R R Magness M J Gething J F Sambrook

Lactase-phlorizin hydrolase (LPH) is expressed on the intestinal brush border and is responsible for the hydrolysis of lactose, the chief sugar in mammalian milk. The enzyme activity of LPH peaks soon after birth in most mammals and declines to much lower levels before adolescence. The molecular basis of this pattern of expression has not been clearly established. We have measured relative amou...

2017
Kevin B. Comerford Gonca Pasin

Each person differs from the next by an average of over 3 million genetic variations in their DNA. This genetic diversity is responsible for many of the interindividual differences in food preferences, nutritional needs, and dietary responses between humans. The field of nutrigenetics aims to utilize this type of genetic information in order to personalize diets for optimal health. One of the m...

2015
Lena Diekmann Katrin Pfeiffer Hassan Y Naim

BACKGROUND Congenital lactase deficiency (CLD) is a rare severe autosomal recessive disorder, with symptoms like watery diarrhea, meteorism and malnutrition, which start a few days after birth by the onset of nursing. The most common rationales identified for this disorder are missense mutations or premature stop codons in the coding region of the lactase-phlorizin hydrolase (LPH) gene. Recentl...

Journal: :Gut 1971
J Garcia-Paredes S C Truelove

Diarrhoea is a common sequel to vagotomy and pyloroplasty but its cause is unknown. One of our patients who developed this complication had an abnormal lactose barium meal and responded well to a lactose-free diet. This led us to make a systematic study of disaccharidase activity in the small intestine in patients with diarrhoea following vagotomy and pyloroplasty. The small-intestinal disaccha...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2011
Marie Lacan Christine Keyser François-Xavier Ricaut Nicolas Brucato Francis Duranthon Jean Guilaine Eric Crubézy Bertrand Ludes

The Neolithic is a key period in the history of the European settlement. Although archaeological and present-day genetic data suggest several hypotheses regarding the human migration patterns at this period, validation of these hypotheses with the use of ancient genetic data has been limited. In this context, we studied DNA extracted from 53 individuals buried in a necropolis used by a French l...

2012
Maryam Alizadeh Ariane Sadr-Nabavi

OBJECTIVES Primary or adult type hypolactasia, the most common enzyme deficiency in the world, is due to reduced lactase activity in the intestinal cell after weaning. Lactase non-persistence is inherited as an autosomal recessive trait. A DNA variant, single nucleotide polymorphism C/T-13910 which is located on 13910 base pairs (bp) upstream of the lactase gene (LCT) at chromosome 2 has been s...

Journal: :The American Journal of Clinical Nutrition 2001

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2001
D M Swallow M Poulter E J Hollox

Intolerance of dietary carbohydrate and sugars can result from a variety of genetically determined enzyme and transporter deficiencies. This article reviews this topic and discusses in more detail the current state of our own research on lactase.

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