Extended-spectrum beta-lactamases (ESBLs) are enzymes found in gram-negative bacilli that mediate resistance to extended-spectrum cephalosporins and aztreonam. In 1999, the National Committee for Clinical Laboratory Standards (NCCLS) published methods for screening and confirming the presence of ESBLs in Klebsiella pneumoniae, Klebsiella oxytoca, and Escherichia coli. To evaluate the confirmati...

T he emergence of multidrug resistant bacteria is a global health problem (1Á3), affecting the management and outcomes of a wide spectrum of infections particularly in hospitals. Resistance contributes to mortality and compromises the healthcare security of nations. Moreover, resistant pathogens are spread between countries by human travel (4Á8), including the medical transfer and evacuation of...

Introduction: Acinetobacter baumannii is a major cause of nosocomial infections which affect mainly disabled patients in intensive care units. The bacteria may acquire resistance to antibiotics and hence can seriously endanger antibiotic therapy. The most important problem facing treatment of A. baumannii is increasing reports of resistance to a wide range of antibiotics, including carbapenems,...

Diabetic foot ulcer (DFU) is a common and devastating complication in diabetes. Antimicrobial resistance mediated by extended-spectrum β-lactamases (ESBLs) production by bacteria is considered to be a major threat for foot amputation. The present study deals with the detection of Escherichia coli and the prevalence of bla(TEM), bla(SHV) and bla(OXA) genes directly from biopsy and swab of foot u...

Sir, Acinetobacter bereziniae, previously known as Acinetobacter genomic species 10, has been isolated primarily from clinical specimens and the hospital environment and more rarely from various other sources, including vegetables, soil and animals. Antibiotic resistance is rarely reported in this species. Over the last decade, carbapenem resistance in Acinetobacter spp., mainly Acinetobacter b...

Abstract Background Triple-action diazabicyclooctanes, e.g. zidebactam, combine ?-lactamase inhibition, antibacterial activity, and ‘enhancement’ of PBP3-targeted ?-lactams. Objectives To examine the activity cefepime/zidebactam against consecutive ‘problem’ Gram-negative bacteria referred to UK national reference laboratory. Methods MICs were determined by BSAC agar dilution for 1632 Enterobac...

Abstract Background The discovery of the superbug mcr-1 -positive Escherichia coli (MCRPEC) has drew greet attention. Swine-origin multi-drug resistant MCRPEC been a potential threat to public health and safety. However, there were few detailed studies have reported on swine in Guangxi, South China. Results In this study, thirty-three strains detected from 142 E. 116 samples Guangxi 2018. Which...